Protection from murine cysticercosis by immunization with a parasite cysteine protease

Salman Baig, Raymond T. Damian, Jorge Morales-Montor, Amr Ghaleb, Amjed Baghdadi, A. Clinton White

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Central nervous system infection by Taenia solium cysts causes neurocysticercosis, a common neurological infection in the Third World. We have previously isolated cysteine proteases from Taenia crassiceps and T. solium. In this study, we immunized BALB/c mice with the purified T. solium cysteine protease and challenged them with Taenia crassiceps. Immunized mice had a 72% reduction in parasite burden compared to mice that received no immunization. Immunized mice developed antigen specific lymphocyte proliferation. These data support further studies of the T. solium cysteine protease as a vaccine candidate.

Original languageEnglish (US)
Pages (from-to)2733-2735
Number of pages3
JournalMicrobes and Infection
Volume8
Issue number12-13
DOIs
StatePublished - Oct 2006
Externally publishedYes

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Keywords

  • Neurocysticercosis
  • Taenia
  • Vaccine

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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