Protection from murine cysticercosis by immunization with a parasite cysteine protease

Salman Baig; Raymond T. Damian; Jorge Morales-Montor; Amr Ghaleb; Amjed Baghdadi; A. Clinton White

doi:10.1016/j.micinf.2006.08.002

Protection from murine cysticercosis by immunization with a parasite cysteine protease

Salman Baig, Raymond T. Damian, Jorge Morales-Montor, Amr Ghaleb, Amjed Baghdadi, A. Clinton White

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Central nervous system infection by Taenia solium cysts causes neurocysticercosis, a common neurological infection in the Third World. We have previously isolated cysteine proteases from Taenia crassiceps and T. solium. In this study, we immunized BALB/c mice with the purified T. solium cysteine protease and challenged them with Taenia crassiceps. Immunized mice had a 72% reduction in parasite burden compared to mice that received no immunization. Immunized mice developed antigen specific lymphocyte proliferation. These data support further studies of the T. solium cysteine protease as a vaccine candidate.

Original language	English (US)
Pages (from-to)	2733-2735
Number of pages	3
Journal	Microbes and Infection
Volume	8
Issue number	12-13
DOIs	https://doi.org/10.1016/j.micinf.2006.08.002
State	Published - Oct 2006
Externally published	Yes

Keywords

Neurocysticercosis
Taenia
Vaccine

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/j.micinf.2006.08.002

Cite this

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title = "Protection from murine cysticercosis by immunization with a parasite cysteine protease",

abstract = "Central nervous system infection by Taenia solium cysts causes neurocysticercosis, a common neurological infection in the Third World. We have previously isolated cysteine proteases from Taenia crassiceps and T. solium. In this study, we immunized BALB/c mice with the purified T. solium cysteine protease and challenged them with Taenia crassiceps. Immunized mice had a 72\% reduction in parasite burden compared to mice that received no immunization. Immunized mice developed antigen specific lymphocyte proliferation. These data support further studies of the T. solium cysteine protease as a vaccine candidate.",

keywords = "Neurocysticercosis, Taenia, Vaccine",

author = "Salman Baig and Damian, \{Raymond T.\} and Jorge Morales-Montor and Amr Ghaleb and Amjed Baghdadi and White, \{A. Clinton\}",

note = "Funding Information: We thank the National Institutes of Health Molecular Parasitology Predoctoral training grant for support of this work and a grant from the US-Mexico Foundation for Science. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2006",

month = oct,

doi = "10.1016/j.micinf.2006.08.002",

language = "English (US)",

volume = "8",

pages = "2733--2735",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson s.r.l.",

number = "12-13",

}

TY - JOUR

T1 - Protection from murine cysticercosis by immunization with a parasite cysteine protease

AU - Baig, Salman

AU - Damian, Raymond T.

AU - Morales-Montor, Jorge

AU - Ghaleb, Amr

AU - Baghdadi, Amjed

AU - White, A. Clinton

N1 - Funding Information: We thank the National Institutes of Health Molecular Parasitology Predoctoral training grant for support of this work and a grant from the US-Mexico Foundation for Science. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2006/10

Y1 - 2006/10

N2 - Central nervous system infection by Taenia solium cysts causes neurocysticercosis, a common neurological infection in the Third World. We have previously isolated cysteine proteases from Taenia crassiceps and T. solium. In this study, we immunized BALB/c mice with the purified T. solium cysteine protease and challenged them with Taenia crassiceps. Immunized mice had a 72% reduction in parasite burden compared to mice that received no immunization. Immunized mice developed antigen specific lymphocyte proliferation. These data support further studies of the T. solium cysteine protease as a vaccine candidate.

AB - Central nervous system infection by Taenia solium cysts causes neurocysticercosis, a common neurological infection in the Third World. We have previously isolated cysteine proteases from Taenia crassiceps and T. solium. In this study, we immunized BALB/c mice with the purified T. solium cysteine protease and challenged them with Taenia crassiceps. Immunized mice had a 72% reduction in parasite burden compared to mice that received no immunization. Immunized mice developed antigen specific lymphocyte proliferation. These data support further studies of the T. solium cysteine protease as a vaccine candidate.

KW - Neurocysticercosis

KW - Taenia

KW - Vaccine

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U2 - 10.1016/j.micinf.2006.08.002

DO - 10.1016/j.micinf.2006.08.002

M3 - Article

C2 - 16979365

AN - SCOPUS:33750622641

SN - 1286-4579

VL - 8

SP - 2733

EP - 2735

JO - Microbes and Infection

JF - Microbes and Infection

IS - 12-13

ER -

Protection from murine cysticercosis by immunization with a parasite cysteine protease

Abstract

Keywords

ASJC Scopus subject areas

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