Protective effect of alcoholic extract of Entada pursaetha DC. Against CCl4-induced hepatotoxicity in rats

Gaurav Gupta, Amar Sunil More, Rashmi Rekha Kumari, Madhu Cholenahalli Lingaraju, Dhirendra Kumar, Dinesh Kumar, Santosh Kumar Mishra, Surender Kumar Tandan

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The alcoholic extract of stem of E. pursaetha (PSE, 30, 100, 300 mg/kg body weight, po for 7 days) showed hepatoprotective activity against CCl4 (2 mL/kg body weight, ip)-induced hepatotoxicity. The extract exhibited a significant dose-dependent hepatoprotective effect comparable to standard drug silymarin, by preventing increase in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, and total bilirubin, lactate dehydrogenase; by lowering hepatic levels of malonaldehyde, nitrate-nitrite, myeloperoxidase activity; enhancing activities of antioxidant enzymes, superoxide dismutase, catalase and increasing reduced glutathione levels in liver, which suggests the antioxidant property of PSE. Histopathological studies also supported the above biochemical parameters. The results suggested that alcoholic extract of E. pursaetha possesses significant hepatoprotective activity in CCl4-induced acute hepatotoxicity in rats and this is likely to be mediated through its antioxidant activities.

Original languageEnglish (US)
Pages (from-to)207-214
Number of pages8
JournalIndian Journal of Experimental Biology
Volume52
Issue number3
StatePublished - Mar 2014

Keywords

  • Antioxidant
  • Entada pursaetha
  • Hepatoprotection Liver toxicity

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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    Gupta, G., More, A. S., Kumari, R. R., Lingaraju, M. C., Kumar, D., Kumar, D., Mishra, S. K., & Tandan, S. K. (2014). Protective effect of alcoholic extract of Entada pursaetha DC. Against CCl4-induced hepatotoxicity in rats. Indian Journal of Experimental Biology, 52(3), 207-214.