Protective effect of alcoholic extract of Entada pursaetha DC. Against CCl4-induced hepatotoxicity in rats

Gaurav Gupta, Amar Sunil More, Rashmi Rekha Kumari, Madhu Cholenahalli Lingaraju, Dhirendra Kumar, Dinesh Kumar, Santosh Kumar Mishra, Surender Kumar Tandan

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The alcoholic extract of stem of E. pursaetha (PSE, 30, 100, 300 mg/kg body weight, po for 7 days) showed hepatoprotective activity against CCl4 (2 mL/kg body weight, ip)-induced hepatotoxicity. The extract exhibited a significant dose-dependent hepatoprotective effect comparable to standard drug silymarin, by preventing increase in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, and total bilirubin, lactate dehydrogenase; by lowering hepatic levels of malonaldehyde, nitrate-nitrite, myeloperoxidase activity; enhancing activities of antioxidant enzymes, superoxide dismutase, catalase and increasing reduced glutathione levels in liver, which suggests the antioxidant property of PSE. Histopathological studies also supported the above biochemical parameters. The results suggested that alcoholic extract of E. pursaetha possesses significant hepatoprotective activity in CCl4-induced acute hepatotoxicity in rats and this is likely to be mediated through its antioxidant activities.

Original languageEnglish (US)
Pages (from-to)207-214
Number of pages8
JournalIndian Journal of Experimental Biology
Volume52
Issue number3
StatePublished - 2014
Externally publishedYes

Fingerprint

Antioxidants
Body Weight
Silymarin
Liver
Nitrites
Aspartate Aminotransferases
Malondialdehyde
Alanine Transaminase
L-Lactate Dehydrogenase
Bilirubin
Nitrates
Catalase
Peroxidase
Superoxide Dismutase
Glutathione
Alkaline Phosphatase
Enzymes
Serum
Pharmaceutical Preparations
Proteins

Keywords

  • Antioxidant
  • Entada pursaetha
  • Hepatoprotection Liver toxicity

ASJC Scopus subject areas

  • Biotechnology
  • Cell Biology
  • Molecular Biology

Cite this

Gupta, G., More, A. S., Kumari, R. R., Lingaraju, M. C., Kumar, D., Kumar, D., ... Tandan, S. K. (2014). Protective effect of alcoholic extract of Entada pursaetha DC. Against CCl4-induced hepatotoxicity in rats. Indian Journal of Experimental Biology, 52(3), 207-214.

Protective effect of alcoholic extract of Entada pursaetha DC. Against CCl4-induced hepatotoxicity in rats. / Gupta, Gaurav; More, Amar Sunil; Kumari, Rashmi Rekha; Lingaraju, Madhu Cholenahalli; Kumar, Dhirendra; Kumar, Dinesh; Mishra, Santosh Kumar; Tandan, Surender Kumar.

In: Indian Journal of Experimental Biology, Vol. 52, No. 3, 2014, p. 207-214.

Research output: Contribution to journalArticle

Gupta, G, More, AS, Kumari, RR, Lingaraju, MC, Kumar, D, Kumar, D, Mishra, SK & Tandan, SK 2014, 'Protective effect of alcoholic extract of Entada pursaetha DC. Against CCl4-induced hepatotoxicity in rats', Indian Journal of Experimental Biology, vol. 52, no. 3, pp. 207-214.
Gupta, Gaurav ; More, Amar Sunil ; Kumari, Rashmi Rekha ; Lingaraju, Madhu Cholenahalli ; Kumar, Dhirendra ; Kumar, Dinesh ; Mishra, Santosh Kumar ; Tandan, Surender Kumar. / Protective effect of alcoholic extract of Entada pursaetha DC. Against CCl4-induced hepatotoxicity in rats. In: Indian Journal of Experimental Biology. 2014 ; Vol. 52, No. 3. pp. 207-214.
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