TY - JOUR
T1 - Protective effect of alcoholic extract of Entada pursaetha DC. Against CCl4-induced hepatotoxicity in rats
AU - Gupta, Gaurav
AU - More, Amar Sunil
AU - Kumari, Rashmi Rekha
AU - Lingaraju, Madhu Cholenahalli
AU - Kumar, Dhirendra
AU - Kumar, Dinesh
AU - Mishra, Santosh Kumar
AU - Tandan, Surender Kumar
PY - 2014/3
Y1 - 2014/3
N2 - The alcoholic extract of stem of E. pursaetha (PSE, 30, 100, 300 mg/kg body weight, po for 7 days) showed hepatoprotective activity against CCl4 (2 mL/kg body weight, ip)-induced hepatotoxicity. The extract exhibited a significant dose-dependent hepatoprotective effect comparable to standard drug silymarin, by preventing increase in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, and total bilirubin, lactate dehydrogenase; by lowering hepatic levels of malonaldehyde, nitrate-nitrite, myeloperoxidase activity; enhancing activities of antioxidant enzymes, superoxide dismutase, catalase and increasing reduced glutathione levels in liver, which suggests the antioxidant property of PSE. Histopathological studies also supported the above biochemical parameters. The results suggested that alcoholic extract of E. pursaetha possesses significant hepatoprotective activity in CCl4-induced acute hepatotoxicity in rats and this is likely to be mediated through its antioxidant activities.
AB - The alcoholic extract of stem of E. pursaetha (PSE, 30, 100, 300 mg/kg body weight, po for 7 days) showed hepatoprotective activity against CCl4 (2 mL/kg body weight, ip)-induced hepatotoxicity. The extract exhibited a significant dose-dependent hepatoprotective effect comparable to standard drug silymarin, by preventing increase in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, and total bilirubin, lactate dehydrogenase; by lowering hepatic levels of malonaldehyde, nitrate-nitrite, myeloperoxidase activity; enhancing activities of antioxidant enzymes, superoxide dismutase, catalase and increasing reduced glutathione levels in liver, which suggests the antioxidant property of PSE. Histopathological studies also supported the above biochemical parameters. The results suggested that alcoholic extract of E. pursaetha possesses significant hepatoprotective activity in CCl4-induced acute hepatotoxicity in rats and this is likely to be mediated through its antioxidant activities.
KW - Antioxidant
KW - Entada pursaetha
KW - Hepatoprotection Liver toxicity
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M3 - Article
C2 - 24669663
AN - SCOPUS:84895874285
SN - 0019-5189
VL - 52
SP - 207
EP - 214
JO - Indian Journal of Experimental Biology
JF - Indian Journal of Experimental Biology
IS - 3
ER -