Protective Effect of Baker's Yeast Mannan against Listeria monocytogenes and Pseudomonas aeruginosa Infection in Mice

Makiko Kobayashi; Masuko Suzuki; Yoshio Okawa; Shigeo Suzuki

doi:10.1248/cpb.38.807

Protective Effect of Baker's Yeast Mannan against Listeria monocytogenes and Pseudomonas aeruginosa Infection in Mice

Makiko Kobayashi, Masuko Suzuki, Yoshio Okawa, Shigeo Suzuki

Internal Medicine

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

The neutral mannan (WNM) and the acidic mannan (WAM025) fractions from baker's yeast (Saccharomyces cerevisiae) were found to manifest significant protective effects against intraperitoneal and intravenous infections of Listeria monocytogenes and Pseudomonas aeruginosa in mice. A remarkable decrease in the number of microbial cells in spleen and liver was observed in mice inoculated with these microorganisms after administration of either mannan fraction. In order to clarify the mechanism of the protective effects, we investigated in vitro the bactericidal activity and lysosomal enzyme activities such as myeloperoxidase, acid phosphatase, and neutral protease, in Kupffer cells (KCs) from mice pretreated with either mannan fraction. KCs from mice administered with these mannan fractions showed an enhanced killing effect on these bacteria in vitro, and neutral protease activity was considered to be one of the important factors in the kiling effect on both L. monocytogenes and P. aeruginosa.

Original language	English (US)
Pages (from-to)	807-809
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	38
Issue number	3
DOIs	https://doi.org/10.1248/cpb.38.807
State	Published - Jan 1 1990

Keywords

Kupffer cell
Listeria monocytogenes
Pseudomonas aeruginosa
infection
mannan
protective effect

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.38.807

Fingerprint Dive into the research topics of 'Protective Effect of Baker's Yeast Mannan against Listeria monocytogenes and Pseudomonas aeruginosa Infection in Mice'. Together they form a unique fingerprint.

Cite this

Kobayashi, M., Suzuki, M., Okawa, Y., & Suzuki, S. (1990). Protective Effect of Baker's Yeast Mannan against Listeria monocytogenes and Pseudomonas aeruginosa Infection in Mice. Chemical and Pharmaceutical Bulletin, 38(3), 807-809. https://doi.org/10.1248/cpb.38.807

@article{96cf4abe765b4880ace995ca44333a85,

title = "Protective Effect of Baker's Yeast Mannan against Listeria monocytogenes and Pseudomonas aeruginosa Infection in Mice",

abstract = "The neutral mannan (WNM) and the acidic mannan (WAM025) fractions from baker's yeast (Saccharomyces cerevisiae) were found to manifest significant protective effects against intraperitoneal and intravenous infections of Listeria monocytogenes and Pseudomonas aeruginosa in mice. A remarkable decrease in the number of microbial cells in spleen and liver was observed in mice inoculated with these microorganisms after administration of either mannan fraction. In order to clarify the mechanism of the protective effects, we investigated in vitro the bactericidal activity and lysosomal enzyme activities such as myeloperoxidase, acid phosphatase, and neutral protease, in Kupffer cells (KCs) from mice pretreated with either mannan fraction. KCs from mice administered with these mannan fractions showed an enhanced killing effect on these bacteria in vitro, and neutral protease activity was considered to be one of the important factors in the kiling effect on both L. monocytogenes and P. aeruginosa.",

keywords = "Kupffer cell, Listeria monocytogenes, Pseudomonas aeruginosa, infection, mannan, protective effect",

author = "Makiko Kobayashi and Masuko Suzuki and Yoshio Okawa and Shigeo Suzuki",

year = "1990",

month = jan,

day = "1",

doi = "10.1248/cpb.38.807",

language = "English (US)",

volume = "38",

pages = "807--809",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "3",

}

TY - JOUR

T1 - Protective Effect of Baker's Yeast Mannan against Listeria monocytogenes and Pseudomonas aeruginosa Infection in Mice

AU - Kobayashi, Makiko

AU - Suzuki, Masuko

AU - Okawa, Yoshio

AU - Suzuki, Shigeo

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The neutral mannan (WNM) and the acidic mannan (WAM025) fractions from baker's yeast (Saccharomyces cerevisiae) were found to manifest significant protective effects against intraperitoneal and intravenous infections of Listeria monocytogenes and Pseudomonas aeruginosa in mice. A remarkable decrease in the number of microbial cells in spleen and liver was observed in mice inoculated with these microorganisms after administration of either mannan fraction. In order to clarify the mechanism of the protective effects, we investigated in vitro the bactericidal activity and lysosomal enzyme activities such as myeloperoxidase, acid phosphatase, and neutral protease, in Kupffer cells (KCs) from mice pretreated with either mannan fraction. KCs from mice administered with these mannan fractions showed an enhanced killing effect on these bacteria in vitro, and neutral protease activity was considered to be one of the important factors in the kiling effect on both L. monocytogenes and P. aeruginosa.

AB - The neutral mannan (WNM) and the acidic mannan (WAM025) fractions from baker's yeast (Saccharomyces cerevisiae) were found to manifest significant protective effects against intraperitoneal and intravenous infections of Listeria monocytogenes and Pseudomonas aeruginosa in mice. A remarkable decrease in the number of microbial cells in spleen and liver was observed in mice inoculated with these microorganisms after administration of either mannan fraction. In order to clarify the mechanism of the protective effects, we investigated in vitro the bactericidal activity and lysosomal enzyme activities such as myeloperoxidase, acid phosphatase, and neutral protease, in Kupffer cells (KCs) from mice pretreated with either mannan fraction. KCs from mice administered with these mannan fractions showed an enhanced killing effect on these bacteria in vitro, and neutral protease activity was considered to be one of the important factors in the kiling effect on both L. monocytogenes and P. aeruginosa.

KW - Kupffer cell

KW - Listeria monocytogenes

KW - Pseudomonas aeruginosa

KW - infection

KW - mannan

KW - protective effect

UR - http://www.scopus.com/inward/record.url?scp=0025168508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025168508&partnerID=8YFLogxK

U2 - 10.1248/cpb.38.807

DO - 10.1248/cpb.38.807

M3 - Article

C2 - 2189582

AN - SCOPUS:0025168508

VL - 38

SP - 807

EP - 809

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 3

ER -