Protective effect of baker's yeast mannan against Listeria monocytogenes and Pseudomonas aeruginosa infection in mice

Makiko Kobayashi, Y. Okawa, S. Suzuki, M. Suzuki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The neutral mannan (WNM) and the acidic mannan (WAM025) fractions from baker's yeast (Saccharomyces cerevisiae) were found to manifest significant protective effects against intraperitoneal and intravenous infections of Listeria monocytogenes and Pseudomonas aeruginosa in mice. A remarkable decrease in the number of microbial cells in spleen and liver was observed in mice inoculated with these microorganisms after administration of either mannan fraction. In order to clarify the mechanism of the protective effects, we investigated in vitro the bactericidal activity and lysosomal enzyme activities such as myeloperoxidase, acid phosphatase, and neutral protease, in Kupffer cells (KCs) from mice pretreated with either mannan fraction. KCs from mice administered with these mannan fractions showed an enhanced killing effect on these bacteria in vitro, and neutral protease activity was considered to be one of the important factors in the killing effect on both L. monocytogenes and P. aeruginosa.

Original languageEnglish (US)
Pages (from-to)807-809
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume38
Issue number3
StatePublished - 1990
Externally publishedYes

Fingerprint

Listeria
Mannans
Pseudomonas Infections
Listeria monocytogenes
Yeast
Pseudomonas aeruginosa
Saccharomyces cerevisiae
Kupffer Cells
Peptide Hydrolases
Enzyme activity
Acid Phosphatase
Microorganisms
Liver
Peroxidase
Bacteria
Spleen
Cell Count
Enzymes
Infection

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Protective effect of baker's yeast mannan against Listeria monocytogenes and Pseudomonas aeruginosa infection in mice. / Kobayashi, Makiko; Okawa, Y.; Suzuki, S.; Suzuki, M.

In: Chemical and Pharmaceutical Bulletin, Vol. 38, No. 3, 1990, p. 807-809.

Research output: Contribution to journalArticle

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