Protective effect of mangiferin on memory impairment: A systematic review

Pei Teng Lum, Mahendran Sekar, Siew Hua Gan, Vijayapandi Pandy, Srinivasa Reddy Bonam

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Memory impairment (MI) is one of the predominant criteria generally used to identify schizophrenia, dementia and amnesia that are associated with neurodegenerative disorders by evaluating patient's cognitive symptoms. To date, there is no available treatment that can completely mitigate MI. Currently, there is a trend in recent investigations towards symptomatic therapy approaches using a variety of natural compounds. Mangiferin is one of them that have been investigated extensively. Mangiferin is a naturally occurring potent glucoxilxanthone and is mainly isolated from the Mangifera indica (Mango) plant. This review is aimed at providing a comprehensive overview on the efficacy of mangiferin on MI, based on in-vivo animal studies. After screening through articles identified from Scopus and PubMed based on the inclusion and exclusion criteria, a total of 11 articles between 2009 and 2019 were included. The minimum and maximum dose of mangiferin were 10 and 200 mg/kg respectively and administered over the period of 12–154 days. The results of 11 articles showed that mangiferin effectively improved spatial recognition, episodic aversive events, short- and long-term memories primarily occurring via its antioxidant and anti-inflammatory effects. The outcomes of the review revealed that mangiferin improves memory and cognitive impairment in different animal models, indicating that it has potential preventive and therapeutic roles in MI.

Original languageEnglish (US)
Pages (from-to)917-927
Number of pages11
JournalSaudi Journal of Biological Sciences
Issue number1
StatePublished - Jan 2021
Externally publishedYes


  • Cognitive
  • Mangifera indica
  • Mangiferin
  • Memory impairment
  • Natural product
  • Neuroprotective

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences


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