Protective effects of glutathione and vitamins on the nutrients of developing chick against methylmercury intoxication

P. P. Sood, N. Sinha, Naseem Ansari

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The investigation provides evidences for the suitability of glutathione, vitamin B complex and vitamin E in the elimination of mercury and restoration of nutritional status in developing chick, pretoxicated with methylmercury chloride (MeHgCl). For this purpose a model was developed taking one day old chick as an experimental subject. Four groups of animals were intoxicated with a daily dose (1 mg/Kg) of MeHgCl for seven days. Out of these, one group was kept without any treatment and sacrificed on the fifteenth day, while the rest were treated separately with vitamin B-complex (20 mg/Kg), vitamin E (60 mg/Kg) and glutathione (50 mg/Kg) for another seven days. All the animals were sacrificed on the fifteenth day. The brain, liver, kidney, muscles, blood and fecal matter were screened analytically and biochemically. Study shows a reduction in the body and tissue weights, deposition of mercury in tissues and decrease of proteins, carbohydrates, lipids, various vitamins and essential minerals in MeHgCl intoxicated animals. The data also reveal, that the monothiol and vitamins are quite efficient in mercury elimination both from nervous and non-nervous tissues of developing chick, and simultaneously restores food and water intake. Such detoxicated animals not only recovered proteins, lipids and carbohydrates and micro-nutrients (vitamins and minerals) leading to the recovery of body weight and maintenance of animal's health, but also provided nutritive and mercury free food to the consumers.

Original languageEnglish (US)
Pages (from-to)3-22
Number of pages20
JournalResearch Communications in Pharmacology and Toxicology
Volume7
Issue number1-2
StatePublished - 2002

Fingerprint

Vitamins
Nutrients
Glutathione
Animals
Mercury
Vitamin B Complex
Food
Tissue
Vitamin E
Minerals
Carbohydrates
Lipids
Nutritional Status
Liver
Drinking
Restoration
Muscle
Brain
Proteins
Blood

Keywords

  • Detoxication
  • Developing chick
  • Elimination of mercury
  • Glutathione
  • Intoxication
  • Methylmercury
  • Nutritional deficiency
  • Pretoxication with methylmercury
  • Restoration of nutritional status
  • Vitamin B complex
  • Vitamin E

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

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title = "Protective effects of glutathione and vitamins on the nutrients of developing chick against methylmercury intoxication",
abstract = "The investigation provides evidences for the suitability of glutathione, vitamin B complex and vitamin E in the elimination of mercury and restoration of nutritional status in developing chick, pretoxicated with methylmercury chloride (MeHgCl). For this purpose a model was developed taking one day old chick as an experimental subject. Four groups of animals were intoxicated with a daily dose (1 mg/Kg) of MeHgCl for seven days. Out of these, one group was kept without any treatment and sacrificed on the fifteenth day, while the rest were treated separately with vitamin B-complex (20 mg/Kg), vitamin E (60 mg/Kg) and glutathione (50 mg/Kg) for another seven days. All the animals were sacrificed on the fifteenth day. The brain, liver, kidney, muscles, blood and fecal matter were screened analytically and biochemically. Study shows a reduction in the body and tissue weights, deposition of mercury in tissues and decrease of proteins, carbohydrates, lipids, various vitamins and essential minerals in MeHgCl intoxicated animals. The data also reveal, that the monothiol and vitamins are quite efficient in mercury elimination both from nervous and non-nervous tissues of developing chick, and simultaneously restores food and water intake. Such detoxicated animals not only recovered proteins, lipids and carbohydrates and micro-nutrients (vitamins and minerals) leading to the recovery of body weight and maintenance of animal's health, but also provided nutritive and mercury free food to the consumers.",
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AU - Sinha, N.

AU - Ansari, Naseem

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N2 - The investigation provides evidences for the suitability of glutathione, vitamin B complex and vitamin E in the elimination of mercury and restoration of nutritional status in developing chick, pretoxicated with methylmercury chloride (MeHgCl). For this purpose a model was developed taking one day old chick as an experimental subject. Four groups of animals were intoxicated with a daily dose (1 mg/Kg) of MeHgCl for seven days. Out of these, one group was kept without any treatment and sacrificed on the fifteenth day, while the rest were treated separately with vitamin B-complex (20 mg/Kg), vitamin E (60 mg/Kg) and glutathione (50 mg/Kg) for another seven days. All the animals were sacrificed on the fifteenth day. The brain, liver, kidney, muscles, blood and fecal matter were screened analytically and biochemically. Study shows a reduction in the body and tissue weights, deposition of mercury in tissues and decrease of proteins, carbohydrates, lipids, various vitamins and essential minerals in MeHgCl intoxicated animals. The data also reveal, that the monothiol and vitamins are quite efficient in mercury elimination both from nervous and non-nervous tissues of developing chick, and simultaneously restores food and water intake. Such detoxicated animals not only recovered proteins, lipids and carbohydrates and micro-nutrients (vitamins and minerals) leading to the recovery of body weight and maintenance of animal's health, but also provided nutritive and mercury free food to the consumers.

AB - The investigation provides evidences for the suitability of glutathione, vitamin B complex and vitamin E in the elimination of mercury and restoration of nutritional status in developing chick, pretoxicated with methylmercury chloride (MeHgCl). For this purpose a model was developed taking one day old chick as an experimental subject. Four groups of animals were intoxicated with a daily dose (1 mg/Kg) of MeHgCl for seven days. Out of these, one group was kept without any treatment and sacrificed on the fifteenth day, while the rest were treated separately with vitamin B-complex (20 mg/Kg), vitamin E (60 mg/Kg) and glutathione (50 mg/Kg) for another seven days. All the animals were sacrificed on the fifteenth day. The brain, liver, kidney, muscles, blood and fecal matter were screened analytically and biochemically. Study shows a reduction in the body and tissue weights, deposition of mercury in tissues and decrease of proteins, carbohydrates, lipids, various vitamins and essential minerals in MeHgCl intoxicated animals. The data also reveal, that the monothiol and vitamins are quite efficient in mercury elimination both from nervous and non-nervous tissues of developing chick, and simultaneously restores food and water intake. Such detoxicated animals not only recovered proteins, lipids and carbohydrates and micro-nutrients (vitamins and minerals) leading to the recovery of body weight and maintenance of animal's health, but also provided nutritive and mercury free food to the consumers.

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