Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria

Areli Gutiérrez-Pérez, Christian Cortés-Rojo, Ruth Noriega-Cisneros, Elizabeth Calderón-Cortés, Salvador Manzo-Avalos, Mónica Clemente-Guerrero, Daniel Godínez-Hernández, Istvan Boldogh, Alfredo Saavedra-Molina

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Trans-resveratrol is a nutraceutical with known antioxidant, anti-inflammatory, cardioprotective, and anti-apoptotic properties. The aim of this study was to evaluate the effects of resveratrol on heart mitochondria. Resveratrol significantly decreased Fe2+ + ascorbate oxidant system-induced lipid peroxide levels, preserved physiological levels of glutathione, and increased nitric oxide (NO) levels in mitochondria. Under calcium-mediated stress, there was a 2.7-fold increase in the NO levels, and a mild decoupling in the mitochondrial respiratory chain. These results provide a mechanism for and support the beneficial effects of resveratrol under pathological conditions induced by oxidative stress and calcium overload. In addition, these findings underscore the usefulness of resveratrol in the prevention of cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
JournalJournal of Bioenergetics and Biomembranes
Volume43
Issue number2
DOIs
StatePublished - Apr 2011

Fingerprint

Heart Mitochondria
Oxidative Stress
Calcium
Nitric Oxide
Lipid Peroxides
Electron Transport
Dietary Supplements
Oxidants
Glutathione
Mitochondria
Anti-Inflammatory Agents
Cardiovascular Diseases
Antioxidants
resveratrol

Keywords

  • Calcium-overload
  • Cardioprotection
  • Mitochondria
  • Oxidative stress
  • Resveratrol

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

Cite this

Gutiérrez-Pérez, A., Cortés-Rojo, C., Noriega-Cisneros, R., Calderón-Cortés, E., Manzo-Avalos, S., Clemente-Guerrero, M., ... Saavedra-Molina, A. (2011). Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria. Journal of Bioenergetics and Biomembranes, 43(2), 101-107. https://doi.org/10.1007/s10863-011-9349-4

Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria. / Gutiérrez-Pérez, Areli; Cortés-Rojo, Christian; Noriega-Cisneros, Ruth; Calderón-Cortés, Elizabeth; Manzo-Avalos, Salvador; Clemente-Guerrero, Mónica; Godínez-Hernández, Daniel; Boldogh, Istvan; Saavedra-Molina, Alfredo.

In: Journal of Bioenergetics and Biomembranes, Vol. 43, No. 2, 04.2011, p. 101-107.

Research output: Contribution to journalArticle

Gutiérrez-Pérez, A, Cortés-Rojo, C, Noriega-Cisneros, R, Calderón-Cortés, E, Manzo-Avalos, S, Clemente-Guerrero, M, Godínez-Hernández, D, Boldogh, I & Saavedra-Molina, A 2011, 'Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria', Journal of Bioenergetics and Biomembranes, vol. 43, no. 2, pp. 101-107. https://doi.org/10.1007/s10863-011-9349-4
Gutiérrez-Pérez A, Cortés-Rojo C, Noriega-Cisneros R, Calderón-Cortés E, Manzo-Avalos S, Clemente-Guerrero M et al. Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria. Journal of Bioenergetics and Biomembranes. 2011 Apr;43(2):101-107. https://doi.org/10.1007/s10863-011-9349-4
Gutiérrez-Pérez, Areli ; Cortés-Rojo, Christian ; Noriega-Cisneros, Ruth ; Calderón-Cortés, Elizabeth ; Manzo-Avalos, Salvador ; Clemente-Guerrero, Mónica ; Godínez-Hernández, Daniel ; Boldogh, Istvan ; Saavedra-Molina, Alfredo. / Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria. In: Journal of Bioenergetics and Biomembranes. 2011 ; Vol. 43, No. 2. pp. 101-107.
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