Protein and healthy aging

Douglas Paddon-Jones, Wayne W. Campbell, Paul F. Jacques, Stephen B. Kritchevsky, Lynn L. Moore, Nancy R. Rodriguez, Luc J C Van Loon

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Our understanding of the potential benefits and challenges of optimizing dietary protein intake in older adults continues to evolve. An overarching hypothesis generated during Protein Summit 2.0 was that consuming an adequate amount of high-quality protein at each meal, in combination with physical activity, may delay the onset of sarcopenia, slow its progression, reduce the magnitude of its functional consequences, or all of these. The potential benefits of young and middle-aged adults adopting a diet pattern whereby adequate protein is consumed at each meal as a countermeasure to sarcopenia are presented and discussed. For example, meeting a protein threshold (∼25-30 g/meal) represents a promising, yet still largely unexplored dietary strategy to help maintain muscle mass and function. For many older adults, breakfast is a carbohydrate-dominated lower-protein meal and represents an opportunity to improve and more evenly distribute daily protein intake. Although both animal and plant-based proteins can provide the required essential amino acids for health, animal proteins generally have a higher proportion of the amino acid leucine. Leucine plays a key role in stimulating translation initiation and muscle protein anabolism and is the focus of ongoing research. Protein requirements should be assessed in the light of habitual physical activity. An evenly distributed protein diet provides a framework that allows older adults to benefit from the synergistic anabolic effect of protein and physical activity. To fully understand the role of dietary protein intake in healthy aging, greater efforts are needed to coordinate and integrate research design and data acquisition and interpretation from a variety of disciplines.

Original languageEnglish (US)
Pages (from-to)1339S-1345S
JournalAmerican Journal of Clinical Nutrition
Volume101
Issue number6
DOIs
StatePublished - Jun 1 2015

Fingerprint

Proteins
Meals
Sarcopenia
Dietary Proteins
Exercise
Leucine
Diet
Anabolic Agents
Plant Proteins
Essential Amino Acids
Breakfast
Muscle Proteins
Research Design
Carbohydrates
Amino Acids
Muscles
Health
Research

Keywords

  • Dietary requirements
  • Muscle
  • Nutrition
  • Protein
  • Sarcopenia

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Paddon-Jones, D., Campbell, W. W., Jacques, P. F., Kritchevsky, S. B., Moore, L. L., Rodriguez, N. R., & Van Loon, L. J. C. (2015). Protein and healthy aging. American Journal of Clinical Nutrition, 101(6), 1339S-1345S. https://doi.org/10.3945/ajcn.114.084061

Protein and healthy aging. / Paddon-Jones, Douglas; Campbell, Wayne W.; Jacques, Paul F.; Kritchevsky, Stephen B.; Moore, Lynn L.; Rodriguez, Nancy R.; Van Loon, Luc J C.

In: American Journal of Clinical Nutrition, Vol. 101, No. 6, 01.06.2015, p. 1339S-1345S.

Research output: Contribution to journalArticle

Paddon-Jones, D, Campbell, WW, Jacques, PF, Kritchevsky, SB, Moore, LL, Rodriguez, NR & Van Loon, LJC 2015, 'Protein and healthy aging', American Journal of Clinical Nutrition, vol. 101, no. 6, pp. 1339S-1345S. https://doi.org/10.3945/ajcn.114.084061
Paddon-Jones D, Campbell WW, Jacques PF, Kritchevsky SB, Moore LL, Rodriguez NR et al. Protein and healthy aging. American Journal of Clinical Nutrition. 2015 Jun 1;101(6):1339S-1345S. https://doi.org/10.3945/ajcn.114.084061
Paddon-Jones, Douglas ; Campbell, Wayne W. ; Jacques, Paul F. ; Kritchevsky, Stephen B. ; Moore, Lynn L. ; Rodriguez, Nancy R. ; Van Loon, Luc J C. / Protein and healthy aging. In: American Journal of Clinical Nutrition. 2015 ; Vol. 101, No. 6. pp. 1339S-1345S.
@article{abcc7a4411fe4577ad879cf42509da15,
title = "Protein and healthy aging",
abstract = "Our understanding of the potential benefits and challenges of optimizing dietary protein intake in older adults continues to evolve. An overarching hypothesis generated during Protein Summit 2.0 was that consuming an adequate amount of high-quality protein at each meal, in combination with physical activity, may delay the onset of sarcopenia, slow its progression, reduce the magnitude of its functional consequences, or all of these. The potential benefits of young and middle-aged adults adopting a diet pattern whereby adequate protein is consumed at each meal as a countermeasure to sarcopenia are presented and discussed. For example, meeting a protein threshold (∼25-30 g/meal) represents a promising, yet still largely unexplored dietary strategy to help maintain muscle mass and function. For many older adults, breakfast is a carbohydrate-dominated lower-protein meal and represents an opportunity to improve and more evenly distribute daily protein intake. Although both animal and plant-based proteins can provide the required essential amino acids for health, animal proteins generally have a higher proportion of the amino acid leucine. Leucine plays a key role in stimulating translation initiation and muscle protein anabolism and is the focus of ongoing research. Protein requirements should be assessed in the light of habitual physical activity. An evenly distributed protein diet provides a framework that allows older adults to benefit from the synergistic anabolic effect of protein and physical activity. To fully understand the role of dietary protein intake in healthy aging, greater efforts are needed to coordinate and integrate research design and data acquisition and interpretation from a variety of disciplines.",
keywords = "Dietary requirements, Muscle, Nutrition, Protein, Sarcopenia",
author = "Douglas Paddon-Jones and Campbell, {Wayne W.} and Jacques, {Paul F.} and Kritchevsky, {Stephen B.} and Moore, {Lynn L.} and Rodriguez, {Nancy R.} and {Van Loon}, {Luc J C}",
year = "2015",
month = "6",
day = "1",
doi = "10.3945/ajcn.114.084061",
language = "English (US)",
volume = "101",
pages = "1339S--1345S",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "6",

}

TY - JOUR

T1 - Protein and healthy aging

AU - Paddon-Jones, Douglas

AU - Campbell, Wayne W.

AU - Jacques, Paul F.

AU - Kritchevsky, Stephen B.

AU - Moore, Lynn L.

AU - Rodriguez, Nancy R.

AU - Van Loon, Luc J C

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Our understanding of the potential benefits and challenges of optimizing dietary protein intake in older adults continues to evolve. An overarching hypothesis generated during Protein Summit 2.0 was that consuming an adequate amount of high-quality protein at each meal, in combination with physical activity, may delay the onset of sarcopenia, slow its progression, reduce the magnitude of its functional consequences, or all of these. The potential benefits of young and middle-aged adults adopting a diet pattern whereby adequate protein is consumed at each meal as a countermeasure to sarcopenia are presented and discussed. For example, meeting a protein threshold (∼25-30 g/meal) represents a promising, yet still largely unexplored dietary strategy to help maintain muscle mass and function. For many older adults, breakfast is a carbohydrate-dominated lower-protein meal and represents an opportunity to improve and more evenly distribute daily protein intake. Although both animal and plant-based proteins can provide the required essential amino acids for health, animal proteins generally have a higher proportion of the amino acid leucine. Leucine plays a key role in stimulating translation initiation and muscle protein anabolism and is the focus of ongoing research. Protein requirements should be assessed in the light of habitual physical activity. An evenly distributed protein diet provides a framework that allows older adults to benefit from the synergistic anabolic effect of protein and physical activity. To fully understand the role of dietary protein intake in healthy aging, greater efforts are needed to coordinate and integrate research design and data acquisition and interpretation from a variety of disciplines.

AB - Our understanding of the potential benefits and challenges of optimizing dietary protein intake in older adults continues to evolve. An overarching hypothesis generated during Protein Summit 2.0 was that consuming an adequate amount of high-quality protein at each meal, in combination with physical activity, may delay the onset of sarcopenia, slow its progression, reduce the magnitude of its functional consequences, or all of these. The potential benefits of young and middle-aged adults adopting a diet pattern whereby adequate protein is consumed at each meal as a countermeasure to sarcopenia are presented and discussed. For example, meeting a protein threshold (∼25-30 g/meal) represents a promising, yet still largely unexplored dietary strategy to help maintain muscle mass and function. For many older adults, breakfast is a carbohydrate-dominated lower-protein meal and represents an opportunity to improve and more evenly distribute daily protein intake. Although both animal and plant-based proteins can provide the required essential amino acids for health, animal proteins generally have a higher proportion of the amino acid leucine. Leucine plays a key role in stimulating translation initiation and muscle protein anabolism and is the focus of ongoing research. Protein requirements should be assessed in the light of habitual physical activity. An evenly distributed protein diet provides a framework that allows older adults to benefit from the synergistic anabolic effect of protein and physical activity. To fully understand the role of dietary protein intake in healthy aging, greater efforts are needed to coordinate and integrate research design and data acquisition and interpretation from a variety of disciplines.

KW - Dietary requirements

KW - Muscle

KW - Nutrition

KW - Protein

KW - Sarcopenia

UR - http://www.scopus.com/inward/record.url?scp=84930457306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930457306&partnerID=8YFLogxK

U2 - 10.3945/ajcn.114.084061

DO - 10.3945/ajcn.114.084061

M3 - Article

VL - 101

SP - 1339S-1345S

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 6

ER -