Protein machines and self assembly in muscle organization

José M. Barral, Henry F. Epstein

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The remarkable order of striated muscle is the result of a complex series of protein interactions at different levels of organization. Within muscle, the thick filament and its major protein myosin are classical examples of functioning protein machines. Our understanding of the structure and assembly of thick filaments and their organization into the regular arrays of the A-band has recently been enhanced by the application of biochemical, genetic, and structural approaches. Detailed studies of the thick filament backbone have shown that the myosins are organized into a tubular structure. Additional protein machines and specific myosin rod sequences have been identified that play significant roles in thick filament structure, assembly, and organization. These include intrinsic filament components, cross-linking molecules of the M-band and constituents of the membrane-cytoskeleton system. Muscle organization is directed by the multistep actions of protein machines that take advantage of well-established self-assembly relationships.

Original languageEnglish (US)
Pages (from-to)813-823
Number of pages11
JournalBioEssays
Volume21
Issue number10
DOIs
StatePublished - Oct 1999
Externally publishedYes

Fingerprint

Self assembly
Muscle
Muscles
muscles
myosin
Myosins
Proteins
proteins
Myosin Subfragments
striated muscle
Striated Muscle
cytoskeleton
Cytoskeleton
crosslinking
molecular genetics
Molecular Biology
Membranes
Molecules

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Protein machines and self assembly in muscle organization. / Barral, José M.; Epstein, Henry F.

In: BioEssays, Vol. 21, No. 10, 10.1999, p. 813-823.

Research output: Contribution to journalArticle

Barral, José M. ; Epstein, Henry F. / Protein machines and self assembly in muscle organization. In: BioEssays. 1999 ; Vol. 21, No. 10. pp. 813-823.
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