Protein metabolism in women and men

Similarities and disparities

Melissa M. Markofski, Elena Volpi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose of review: To provide an objective and comprehensive review of the recent literature addressing the effects of sex on protein metabolism. We also evaluate whether these differences can be attributed to physiology or methodology. Because of the developmental changes in hormonal milieu and body composition that occur across life, the literature has been examined in a longitudinal manner across the lifespan. Recent findings: Throughout most points of life, men and women of similar health status and BMI display fairly similar protein turnover rates. However, some investigators have reported sexual dimorphism in protein metabolism, which may be partly attributable to differences in fat-free mass and/or methodology. In periods of significant changes in the hormonal milieu (puberty and menopause), sex differences may become more evident. Finally, anabolic stimuli such as feeding and exercise may help highlight any discrepancies in protein turnover between men and women. Summary: Sex differences in protein metabolism, if any, are most evident during the main phases of hormonal changes, and may be also due to differences in body composition. However, methodological issues and sample size must be considered when designing and evaluating these studies.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Volume14
Issue number1
DOIs
StatePublished - Jan 2011

Fingerprint

Sex Characteristics
Body Composition
Proteins
Women's Health
Puberty
Menopause
Sample Size
Health Status
Fats
Research Personnel
Exercise

Keywords

  • Protein turnover
  • Sex
  • Stable isotope tracers

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Protein metabolism in women and men : Similarities and disparities. / Markofski, Melissa M.; Volpi, Elena.

In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 14, No. 1, 01.2011, p. 93-97.

Research output: Contribution to journalArticle

@article{b52afb9c9fdc4051a66439fc19272a94,
title = "Protein metabolism in women and men: Similarities and disparities",
abstract = "Purpose of review: To provide an objective and comprehensive review of the recent literature addressing the effects of sex on protein metabolism. We also evaluate whether these differences can be attributed to physiology or methodology. Because of the developmental changes in hormonal milieu and body composition that occur across life, the literature has been examined in a longitudinal manner across the lifespan. Recent findings: Throughout most points of life, men and women of similar health status and BMI display fairly similar protein turnover rates. However, some investigators have reported sexual dimorphism in protein metabolism, which may be partly attributable to differences in fat-free mass and/or methodology. In periods of significant changes in the hormonal milieu (puberty and menopause), sex differences may become more evident. Finally, anabolic stimuli such as feeding and exercise may help highlight any discrepancies in protein turnover between men and women. Summary: Sex differences in protein metabolism, if any, are most evident during the main phases of hormonal changes, and may be also due to differences in body composition. However, methodological issues and sample size must be considered when designing and evaluating these studies.",
keywords = "Protein turnover, Sex, Stable isotope tracers",
author = "Markofski, {Melissa M.} and Elena Volpi",
year = "2011",
month = "1",
doi = "10.1097/MCO.0b013e3283412343",
language = "English (US)",
volume = "14",
pages = "93--97",
journal = "Current Opinion in Clinical Nutrition and Metabolic Care",
issn = "1363-1950",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Protein metabolism in women and men

T2 - Similarities and disparities

AU - Markofski, Melissa M.

AU - Volpi, Elena

PY - 2011/1

Y1 - 2011/1

N2 - Purpose of review: To provide an objective and comprehensive review of the recent literature addressing the effects of sex on protein metabolism. We also evaluate whether these differences can be attributed to physiology or methodology. Because of the developmental changes in hormonal milieu and body composition that occur across life, the literature has been examined in a longitudinal manner across the lifespan. Recent findings: Throughout most points of life, men and women of similar health status and BMI display fairly similar protein turnover rates. However, some investigators have reported sexual dimorphism in protein metabolism, which may be partly attributable to differences in fat-free mass and/or methodology. In periods of significant changes in the hormonal milieu (puberty and menopause), sex differences may become more evident. Finally, anabolic stimuli such as feeding and exercise may help highlight any discrepancies in protein turnover between men and women. Summary: Sex differences in protein metabolism, if any, are most evident during the main phases of hormonal changes, and may be also due to differences in body composition. However, methodological issues and sample size must be considered when designing and evaluating these studies.

AB - Purpose of review: To provide an objective and comprehensive review of the recent literature addressing the effects of sex on protein metabolism. We also evaluate whether these differences can be attributed to physiology or methodology. Because of the developmental changes in hormonal milieu and body composition that occur across life, the literature has been examined in a longitudinal manner across the lifespan. Recent findings: Throughout most points of life, men and women of similar health status and BMI display fairly similar protein turnover rates. However, some investigators have reported sexual dimorphism in protein metabolism, which may be partly attributable to differences in fat-free mass and/or methodology. In periods of significant changes in the hormonal milieu (puberty and menopause), sex differences may become more evident. Finally, anabolic stimuli such as feeding and exercise may help highlight any discrepancies in protein turnover between men and women. Summary: Sex differences in protein metabolism, if any, are most evident during the main phases of hormonal changes, and may be also due to differences in body composition. However, methodological issues and sample size must be considered when designing and evaluating these studies.

KW - Protein turnover

KW - Sex

KW - Stable isotope tracers

UR - http://www.scopus.com/inward/record.url?scp=79851509621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79851509621&partnerID=8YFLogxK

U2 - 10.1097/MCO.0b013e3283412343

DO - 10.1097/MCO.0b013e3283412343

M3 - Article

VL - 14

SP - 93

EP - 97

JO - Current Opinion in Clinical Nutrition and Metabolic Care

JF - Current Opinion in Clinical Nutrition and Metabolic Care

SN - 1363-1950

IS - 1

ER -