Protein supplementation increases Postexercise plasma Myostatin concentration after 8 weeks of resistance training in young physically active subjects

Antonio Paoli, Quirico F. Pacelli, Marco Neri, Luana Toniolo, Pasqua Cancellara, Marta Canato, Tatiana Moro, Marco Quadrelli, Aldo Morra, Diego Faggian, Mario Plebani, Antonino Bianco, Carlo Reggiani

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9 Scopus citations

Abstract

Myostatin (MSTN) is a negative regulator of muscle growth even if some studies have shown a counterintuitive positive correlation between MSTN and muscle mass (MM). Our aim was to investigate the influence of 2 months of resistance training (RT) and diets with different protein contents on plasma MSTN, interleukin 1 beta (IL-1β), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and insulin-like growth factor 1 (IGF-1). Eighteen healthy volunteers were randomly divided in two groups: high protein (HP) and normal protein (NP) groups. Different protein diet contents were 1.8 and 0.85g of protein kg bw-1 day-1 for HP and NP, respectively. Subjects underwent 8 weeks of standardized progressive RT. MSTN, IGF-1, IL-1β, IL-6, and TNF-α were analyzed before and after the first and the last training sessions. Lean body mass, MM, upper-limb muscle area, and strength were measured. Plasma MSTN showed a significant increase (P<.001) after the last training in the HP group compared with NP group and with starting value. IGF-1 plasma concentration showed a positive correlation with MSTN in HP after the last training (r2=0.6456; P=.0295). No significant differences were found between NP and HP for IL-1β, IL-6, TNF-α, and strength and MM or area. These findings suggest a "paradoxical" postexercise increase of plasma MSTN after 8 weeks of RT and HP diets. This MSTN elevation correlates positively with IGF-1 plasma level. This double increase of opposite (catabolic/anabolic) mediators could explain the substantial overlapping of MM increases in the two groups.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalJournal of Medicinal Food
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • cytokines
  • diet
  • exercise
  • myostatin
  • nutritional supplement

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Paoli, A., Pacelli, Q. F., Neri, M., Toniolo, L., Cancellara, P., Canato, M., Moro, T., Quadrelli, M., Morra, A., Faggian, D., Plebani, M., Bianco, A., & Reggiani, C. (2015). Protein supplementation increases Postexercise plasma Myostatin concentration after 8 weeks of resistance training in young physically active subjects. Journal of Medicinal Food, 18(1), 137-143. https://doi.org/10.1089/jmf.2014.0004