Proteins of Multiple Classes May Participate in Nongenomic Steroid Actions

Cheryl S. Watson, Bahiru Gametchu

    Research output: Contribution to journalArticle

    68 Citations (Scopus)

    Abstract

    Responses to steroids initiated from non-nuclear receptors impinge on a wide variety of cellular responses and utilize nearly all known signal transduction webs. While the mechanisms by which steroid receptors localize in the membrane are still unclear, it is apparent that this alternative localization allows steroid receptors to participate in a wide range of complex functions influencing cell proliferation, death, and differentiation. The central debate still remains the identity of the protein class or classes that mediate membrane-initiated (nongenomic) responses. The data thus far have supported several possibilities, including: nuclear steroid receptor-like forms in non-nuclear locations; other known (nonsteroid) membrane receptors or channels with additional steroid-binding sites; enzymes; transporters; receptors for serum steroid-binding proteins; unique and previously undescribed proteins; or chimeras of typical steroid receptor domains with other unique or known protein domains. Categorizing membrane steroid receptor proteins based exclusively on the actions of antagonists and agonists, without considering cell context and protein partnering issues, may mislead us into predicting more receptor subtypes than really exist. However, the plethora of signaling and functional outcomes may indicate the participation of more than one kind of steroid-binding protein. Resolving such unanswered questions will require future investigative focus on this alternative arm of steroid action, which is likely to yield as many therapeutic opportunities as have nuclear steroid mechanisms.

    Original languageEnglish
    Pages (from-to)1272-1281
    Number of pages10
    JournalExperimental Biology and Medicine
    Volume228
    Issue number11
    StatePublished - Dec 2003

    Fingerprint

    Steroid Receptors
    Steroids
    Membranes
    Proteins
    Carrier Proteins
    Signal transduction
    Cell proliferation
    Cytoplasmic and Nuclear Receptors
    Cell Differentiation
    Signal Transduction
    Cell Death
    Binding Sites
    Cell Proliferation
    Enzymes
    Serum

    Keywords

    • Protein kinases
    • Protein partners
    • Receptors
    • Signaling
    • Steroid-binding proteins
    • Subcellular localization

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Proteins of Multiple Classes May Participate in Nongenomic Steroid Actions. / Watson, Cheryl S.; Gametchu, Bahiru.

    In: Experimental Biology and Medicine, Vol. 228, No. 11, 12.2003, p. 1272-1281.

    Research output: Contribution to journalArticle

    Watson, Cheryl S. ; Gametchu, Bahiru. / Proteins of Multiple Classes May Participate in Nongenomic Steroid Actions. In: Experimental Biology and Medicine. 2003 ; Vol. 228, No. 11. pp. 1272-1281.
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