Proteins with glycosylphosphatidylinositol (GPI) signal sequences have divergent fates during a GPI deficiency. GPIs are essential for nuclear division in Trypanosoma cruzi

Medicine & Life Sciences

• Glycosylphosphatidylinositol deficiency 100%
• Cell Nucleus Division 75%
• Glycosylphosphatidylinositols 67%
• Trypanosoma cruzi 62%
• Protein Sorting Signals 56%
• Proteins 19%
• brain synaptic membrane glycoprotein gp 50 7%
• transamidases 6%
• Parasites 6%
• Chagas Disease 4%
• Loss of Function Mutation 4%
• Type C Phospholipases 4%
• Genetic Background 3%
• Mitosis 3%
• Peptide Hydrolases 3%
• Membrane Proteins 3%
• Membranes 2%

Chemical Compounds

• Glycosylphosphatidylinositol 78%
• Protein 21%
• Mammalian Cell 5%
• Mutation 4%
• Surface 3%