Proteomic analysis of global alteration of protein expression in squamous cell carcinoma of the esophagus

Ge Zhou, Hongmei Li, Yi Gong, Yingxin Zhao, Jingke Cheng, Peng Lee, Yingming Zhao

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Squamous cell carcinoma of the esophagus (ESCC), a major subtype of esophageal carcinoma, is one of the aggressive cancers with worst prognosis in the world. The dismal outcome of ESCC is attributed to multiple reasons including its aggressive nature, largely unknown molecular mechanism of its progression, and the lack of biomarkers for early detection and effective prediction of its clinical behavior. To identify proteins with prognostic and/or predictive value, we applied a proteomics strategy to quantify proteins differentially expressed in ESCC using matched samples of carcinoma and adjacent normal epithelial cells. The analysis led to identification of 28 proteins aberrantly expressed in cancer cells with changes of at least three-fold in ESCC relative to normal squamous epithelial cells. These changes represent functional alterations of essential proteins for normal cellular physiology, accounting for many cellular changes involved in development of ESCC, including cell transformation, loss of differentiation, tumor growth, apoptosis, tumor invasion, and cell metabolism. The differentially expressed proteins shed new insights on the mechanism of tumorigenesis and provide candidate biomarkers for early detection of ESCC.

Original languageEnglish (US)
Pages (from-to)3814-3821
Number of pages8
JournalProteomics
Volume5
Issue number14
DOIs
StatePublished - Sep 2005
Externally publishedYes

Fingerprint

Proteomics
Esophagus
Squamous Cell Carcinoma
Biomarkers
Proteins
Tumors
Neoplasms
Epithelial Cells
Carcinoma
Physiology
Metabolism
Carcinogenesis
Cells
Apoptosis
Growth

Keywords

  • Cancer-specific protein marker
  • Esophageal squamous cell carcinoma

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Proteomic analysis of global alteration of protein expression in squamous cell carcinoma of the esophagus. / Zhou, Ge; Li, Hongmei; Gong, Yi; Zhao, Yingxin; Cheng, Jingke; Lee, Peng; Zhao, Yingming.

In: Proteomics, Vol. 5, No. 14, 09.2005, p. 3814-3821.

Research output: Contribution to journalArticle

Zhou, Ge ; Li, Hongmei ; Gong, Yi ; Zhao, Yingxin ; Cheng, Jingke ; Lee, Peng ; Zhao, Yingming. / Proteomic analysis of global alteration of protein expression in squamous cell carcinoma of the esophagus. In: Proteomics. 2005 ; Vol. 5, No. 14. pp. 3814-3821.
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