Proteomic insights into inflammatory airway diseases

Allan R. Brasier, William Calhoun

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Airways disease presenting as viral bronchiolitis, asthma and chronic obstructive pulmonary disease (COPD) is an increasingly important source of morbidity in Western Countries. Although these diseases affect distinct age groups, have different initiators and manifest variable amounts of parenchymal remodeling, each process is driven by a common fundamental process involving cellular inflammation. Inflammation is a coordinated multi-cellular response to the presence of pathogens or allergens culminating in altering resident leukocyte populations and remodeling structural tissues in the lung. In this review, we will discuss the contributions of innate and chronic adaptive immunity underlying inflammation seen in bronchiolitis, asthma, both mild and severe, and COPD. We will illustrate how applications of proteomics have begun to provide new insights into critical questions regarding the cellular and innate response to inflammation, role of reactive oxygen stress, identification of phenotypic subgroups using molecular profiling, and how proteomics provides insights into therapeutic responses. We will discuss the available sampling strategies for airway biofluids (bronchoalveolar lavage, induced sputum, exhaled bronchial breath condensates, and nasopharyngeal aspiration) and the advantages and limitations of each. Selectively applied and properly designed proteomics studies provide an added dimension of information to reduce the impact and burden of these common inflammatory airway diseases.

Original languageEnglish (US)
Pages (from-to)84-96
Number of pages13
JournalCurrent Proteomics
Volume8
Issue number2
StatePublished - Jul 2011

Fingerprint

Proteomics
Pulmonary diseases
Inflammation
Chronic Obstructive Pulmonary Disease
Viral Bronchiolitis
Asthma
Pathogens
Allergens
Bronchiolitis
Adaptive Immunity
Bronchoalveolar Lavage
Sputum
Tissue
Oxygen
Sampling
Leukocytes
Age Groups
Morbidity
Lung
Population

Keywords

  • Asthma
  • inflammation
  • innate immunity
  • proteomics
  • Reactive oxygen species (ros)
  • RIG-I
  • tandem affinity purification/molecular profiling

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Proteomic insights into inflammatory airway diseases. / Brasier, Allan R.; Calhoun, William.

In: Current Proteomics, Vol. 8, No. 2, 07.2011, p. 84-96.

Research output: Contribution to journalArticle

Brasier, Allan R. ; Calhoun, William. / Proteomic insights into inflammatory airway diseases. In: Current Proteomics. 2011 ; Vol. 8, No. 2. pp. 84-96.
@article{f8c0bccd70034199a340a31d37f8a112,
title = "Proteomic insights into inflammatory airway diseases",
abstract = "Airways disease presenting as viral bronchiolitis, asthma and chronic obstructive pulmonary disease (COPD) is an increasingly important source of morbidity in Western Countries. Although these diseases affect distinct age groups, have different initiators and manifest variable amounts of parenchymal remodeling, each process is driven by a common fundamental process involving cellular inflammation. Inflammation is a coordinated multi-cellular response to the presence of pathogens or allergens culminating in altering resident leukocyte populations and remodeling structural tissues in the lung. In this review, we will discuss the contributions of innate and chronic adaptive immunity underlying inflammation seen in bronchiolitis, asthma, both mild and severe, and COPD. We will illustrate how applications of proteomics have begun to provide new insights into critical questions regarding the cellular and innate response to inflammation, role of reactive oxygen stress, identification of phenotypic subgroups using molecular profiling, and how proteomics provides insights into therapeutic responses. We will discuss the available sampling strategies for airway biofluids (bronchoalveolar lavage, induced sputum, exhaled bronchial breath condensates, and nasopharyngeal aspiration) and the advantages and limitations of each. Selectively applied and properly designed proteomics studies provide an added dimension of information to reduce the impact and burden of these common inflammatory airway diseases.",
keywords = "Asthma, inflammation, innate immunity, proteomics, Reactive oxygen species (ros), RIG-I, tandem affinity purification/molecular profiling",
author = "Brasier, {Allan R.} and William Calhoun",
year = "2011",
month = "7",
language = "English (US)",
volume = "8",
pages = "84--96",
journal = "Current Proteomics",
issn = "1570-1646",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - Proteomic insights into inflammatory airway diseases

AU - Brasier, Allan R.

AU - Calhoun, William

PY - 2011/7

Y1 - 2011/7

N2 - Airways disease presenting as viral bronchiolitis, asthma and chronic obstructive pulmonary disease (COPD) is an increasingly important source of morbidity in Western Countries. Although these diseases affect distinct age groups, have different initiators and manifest variable amounts of parenchymal remodeling, each process is driven by a common fundamental process involving cellular inflammation. Inflammation is a coordinated multi-cellular response to the presence of pathogens or allergens culminating in altering resident leukocyte populations and remodeling structural tissues in the lung. In this review, we will discuss the contributions of innate and chronic adaptive immunity underlying inflammation seen in bronchiolitis, asthma, both mild and severe, and COPD. We will illustrate how applications of proteomics have begun to provide new insights into critical questions regarding the cellular and innate response to inflammation, role of reactive oxygen stress, identification of phenotypic subgroups using molecular profiling, and how proteomics provides insights into therapeutic responses. We will discuss the available sampling strategies for airway biofluids (bronchoalveolar lavage, induced sputum, exhaled bronchial breath condensates, and nasopharyngeal aspiration) and the advantages and limitations of each. Selectively applied and properly designed proteomics studies provide an added dimension of information to reduce the impact and burden of these common inflammatory airway diseases.

AB - Airways disease presenting as viral bronchiolitis, asthma and chronic obstructive pulmonary disease (COPD) is an increasingly important source of morbidity in Western Countries. Although these diseases affect distinct age groups, have different initiators and manifest variable amounts of parenchymal remodeling, each process is driven by a common fundamental process involving cellular inflammation. Inflammation is a coordinated multi-cellular response to the presence of pathogens or allergens culminating in altering resident leukocyte populations and remodeling structural tissues in the lung. In this review, we will discuss the contributions of innate and chronic adaptive immunity underlying inflammation seen in bronchiolitis, asthma, both mild and severe, and COPD. We will illustrate how applications of proteomics have begun to provide new insights into critical questions regarding the cellular and innate response to inflammation, role of reactive oxygen stress, identification of phenotypic subgroups using molecular profiling, and how proteomics provides insights into therapeutic responses. We will discuss the available sampling strategies for airway biofluids (bronchoalveolar lavage, induced sputum, exhaled bronchial breath condensates, and nasopharyngeal aspiration) and the advantages and limitations of each. Selectively applied and properly designed proteomics studies provide an added dimension of information to reduce the impact and burden of these common inflammatory airway diseases.

KW - Asthma

KW - inflammation

KW - innate immunity

KW - proteomics

KW - Reactive oxygen species (ros)

KW - RIG-I

KW - tandem affinity purification/molecular profiling

UR - http://www.scopus.com/inward/record.url?scp=79958264464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958264464&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:79958264464

VL - 8

SP - 84

EP - 96

JO - Current Proteomics

JF - Current Proteomics

SN - 1570-1646

IS - 2

ER -