Proteomics and the analysis of proteomic data: an overview of current protein-profiling technologies.

Erol E. Gulcicek, Christopher M. Colangelo, Walter McMurray, Kathryn Stone, Kenneth Williams, Terence Wu, Hongyu Zhao, Heidi Spratt, Alexander Kurosky, Baolin Wu

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

In recent years, several proteomic methodologies have been developed that now make it possible to identify, characterize, and comparatively quantify the relative level of expression of hundreds of proteins that are coexpressed in a given cell type or tissue, or that are found in biological fluids such as serum. These advances have resulted from the integration of diverse scientific disciplines including molecular and cellular biology, protein/peptide chemistry, bioinformatics, analytical and bioanalytical chemistry, and the use of instrumental and software tools such as multidimensional electrophoretic and chromatographic separations and mass spectrometry. In this unit, some of the common protein-profiling technologies are reviewed, along with the accompanying data-analysis tools.

Original languageEnglish (US)
Pages (from-to)Unit 13.1
JournalCurrent protocols in bioinformatics / editoral board, Andreas D. Baxevanis ... [et al.]
VolumeChapter 13
StatePublished - Jul 2005

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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    Gulcicek, E. E., Colangelo, C. M., McMurray, W., Stone, K., Williams, K., Wu, T., Zhao, H., Spratt, H., Kurosky, A., & Wu, B. (2005). Proteomics and the analysis of proteomic data: an overview of current protein-profiling technologies. Current protocols in bioinformatics / editoral board, Andreas D. Baxevanis ... [et al.], Chapter 13, Unit 13.1.