Proteomics of airway inflammatory cells in asthma research

Konrad Pazdrak

    Research output: Contribution to journalReview article

    Abstract

    Considerable research indicates that many cells of the asthmatic airway become dysfunctional. There is clear evidence for epithelial and airway smooth muscle cell dysfunction, accumulation of activated T cells, and systemic inflammation effects on peripheral blood granulocytes. A number of studies of airway cells have applied proteomics, resulting in mapped protein profiles of inflammatory cells and increased understanding of potential mechanisms involved in allergic inflammation. The reports described in this review offer many encouraging leads for further detailed analysis of allergic processes. The elucidation of their role in asthma will require the application of novel technologies and insightful biochemical interpretation. There is considerable optimism that comparative proteomic investigation of airway inflammatory cells may provide critical insights into the phenotypes of asthma and will reveal novel mechanistic targets for therapeutic interventions.

    Original languageEnglish (US)
    Pages (from-to)111-124
    Number of pages14
    JournalCurrent Proteomics
    Volume8
    Issue number2
    DOIs
    StatePublished - Jul 2011

    Keywords

    • Airway inflammation
    • Allergic asthma
    • Cellular proteomics
    • Eosinophil

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology

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