Pseudoepitheliomatous hyperplasia mistaken for cancer after delayed reconstruction

Karen H. Calhoun, Richard F. Wagner, Dhruv Kumar, James A. Hokanson

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Pseudoepitheliomatous hyperplasia (PEH) arises in areas of chronic inflammation and can be mistaken for squamous cell carcinoma, leading to unnecessary removal of more tissue. We present a study of 21 patients having delayed reconstruction of defects left by Mohs micrographic surgery (MMS) to remove facial skin cancers. Reconstruction was done at an average of 6 days after MMS. Four of these 21 patients (19%) had PEH in the wound margins. Presence of PEH did not correlate with age, sex, delay in reconstruction, frequency of wound care, size or location of the defect, type of tumor, or smoking status. During an average 24-month follow-up, none of these four patients had tumor recurrence, suggesting that the benign diagnosis of PEH was correct. We detail the histologic features of PEH, and describe techniques for minimizing confusion with squamous cell carcinoma.

Original languageEnglish (US)
Pages (from-to)454-457
Number of pages4
JournalSouthern medical journal
Issue number4
StatePublished - Apr 1995

ASJC Scopus subject areas

  • General Medicine


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