Pseudointimal Biliary Epithelial Proliferation and Zahn's Infarct Associated with a 61/2‐month‐old Transjugular Intrahepatic Portosystemic Shunt

L. Clarke Stout, Robert E. Lyon, Natalie G.B. Murray, Merle H. Barth

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Abstract

The transjugular intrahepatic portosystemic shunt has recently become widely used for portal decompression. Shunt stenosis resulting from pseudointinml hyperplasia and hepatic encephalopathy are emerging an important midterm complications of the procedure. Bile extravasation caused by bile duct transection by the stent wires has been suggested as a cause of the pseudointimal hyperplasia. The present case report describes a 61/2‐month‐old trunsjugutar intrahepatic portosystemic shunt in which apparent biliary epithelial proliferation had formed large cyst‐like spaces within the pseudointima at the site of shunt stenosis. We hypothesize that secretory products from these biliary epithelial cells may have contributed to shunt stenosis by creating expansile cysts or by stimulating pseudointimal hyperplasia. In addition, we found a large, recent Zahn's infarct adjacent to the stent. Pseudointimal hyperplasia had extended from the stent wires into the orifices of contiguous small portal and hepatic vein branches. The resulting stenosis of these small veins may have contributed to the Zahn's infarct.

Original languageEnglish (US)
Pages (from-to)126-130
Number of pages5
JournalThe American Journal of Gastroenterology
Volume90
Issue number1
DOIs
StatePublished - Jan 1995

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ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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