PTHrP increases xenograft growth and promotes integrin α6β4 expression and Akt activation in colon cancer

Xiaoli Shen, Piotr G. Rychahou, B. Mark Evers, Miriam Falzon

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Parathyroid hormone-related protein (PTHrP) is expressed by human colon cancer tissue and cell lines. Expression of PTHrP and phosphatidylinositol 3-kinase (PI3-K) pathway components correlates with the severity of colon carcinoma. Here we observed a positive effect of endogenous PTHrP on LoVo (human colon cancer) cell proliferation, migration, invasion, integrin α6 and β4 expression, and p-Akt levels. There was a direct correlation between PTHrP expression and anchorage-independent cell growth. PTHrP significantly increased xenograft growth; tumors from PTHrP-overexpressing cells showed increased expression of integrins α6 and β4, and PI3-K pathway components. The higher expression of PTHrP in human colon cancer adenocarcinoma vs. normal colonic mucosa was accompanied by increased integrin α6 and β4 levels. Elevated PTHrP expression in colon cancer may thus upregulate integrin α6β4 expression, with consequent PI3-K activation. Targeting PTHrP might result in effective inhibition of tumor growth, migration, and invasion.

Original languageEnglish (US)
Pages (from-to)241-252
Number of pages12
JournalCancer Letters
Volume258
Issue number2
DOIs
StatePublished - Dec 18 2007

Fingerprint

Parathyroid Hormone-Related Protein
Heterografts
Integrins
Colonic Neoplasms
Growth
Phosphatidylinositol 3-Kinase
Cell Movement
Neoplasms
Colon
Mucous Membrane
Adenocarcinoma
Up-Regulation
Cell Proliferation
Carcinoma
Cell Line

Keywords

  • Colon cancer
  • Integrin α6β4
  • Phosphatidylinositol 3-kinase
  • PTHrP

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

PTHrP increases xenograft growth and promotes integrin α6β4 expression and Akt activation in colon cancer. / Shen, Xiaoli; Rychahou, Piotr G.; Evers, B. Mark; Falzon, Miriam.

In: Cancer Letters, Vol. 258, No. 2, 18.12.2007, p. 241-252.

Research output: Contribution to journalArticle

Shen, Xiaoli ; Rychahou, Piotr G. ; Evers, B. Mark ; Falzon, Miriam. / PTHrP increases xenograft growth and promotes integrin α6β4 expression and Akt activation in colon cancer. In: Cancer Letters. 2007 ; Vol. 258, No. 2. pp. 241-252.
@article{b55fd2ac7b1a44ce8664ed6586d58198,
title = "PTHrP increases xenograft growth and promotes integrin α6β4 expression and Akt activation in colon cancer",
abstract = "Parathyroid hormone-related protein (PTHrP) is expressed by human colon cancer tissue and cell lines. Expression of PTHrP and phosphatidylinositol 3-kinase (PI3-K) pathway components correlates with the severity of colon carcinoma. Here we observed a positive effect of endogenous PTHrP on LoVo (human colon cancer) cell proliferation, migration, invasion, integrin α6 and β4 expression, and p-Akt levels. There was a direct correlation between PTHrP expression and anchorage-independent cell growth. PTHrP significantly increased xenograft growth; tumors from PTHrP-overexpressing cells showed increased expression of integrins α6 and β4, and PI3-K pathway components. The higher expression of PTHrP in human colon cancer adenocarcinoma vs. normal colonic mucosa was accompanied by increased integrin α6 and β4 levels. Elevated PTHrP expression in colon cancer may thus upregulate integrin α6β4 expression, with consequent PI3-K activation. Targeting PTHrP might result in effective inhibition of tumor growth, migration, and invasion.",
keywords = "Colon cancer, Integrin α6β4, Phosphatidylinositol 3-kinase, PTHrP",
author = "Xiaoli Shen and Rychahou, {Piotr G.} and Evers, {B. Mark} and Miriam Falzon",
year = "2007",
month = "12",
day = "18",
doi = "10.1016/j.canlet.2007.09.010",
language = "English (US)",
volume = "258",
pages = "241--252",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - PTHrP increases xenograft growth and promotes integrin α6β4 expression and Akt activation in colon cancer

AU - Shen, Xiaoli

AU - Rychahou, Piotr G.

AU - Evers, B. Mark

AU - Falzon, Miriam

PY - 2007/12/18

Y1 - 2007/12/18

N2 - Parathyroid hormone-related protein (PTHrP) is expressed by human colon cancer tissue and cell lines. Expression of PTHrP and phosphatidylinositol 3-kinase (PI3-K) pathway components correlates with the severity of colon carcinoma. Here we observed a positive effect of endogenous PTHrP on LoVo (human colon cancer) cell proliferation, migration, invasion, integrin α6 and β4 expression, and p-Akt levels. There was a direct correlation between PTHrP expression and anchorage-independent cell growth. PTHrP significantly increased xenograft growth; tumors from PTHrP-overexpressing cells showed increased expression of integrins α6 and β4, and PI3-K pathway components. The higher expression of PTHrP in human colon cancer adenocarcinoma vs. normal colonic mucosa was accompanied by increased integrin α6 and β4 levels. Elevated PTHrP expression in colon cancer may thus upregulate integrin α6β4 expression, with consequent PI3-K activation. Targeting PTHrP might result in effective inhibition of tumor growth, migration, and invasion.

AB - Parathyroid hormone-related protein (PTHrP) is expressed by human colon cancer tissue and cell lines. Expression of PTHrP and phosphatidylinositol 3-kinase (PI3-K) pathway components correlates with the severity of colon carcinoma. Here we observed a positive effect of endogenous PTHrP on LoVo (human colon cancer) cell proliferation, migration, invasion, integrin α6 and β4 expression, and p-Akt levels. There was a direct correlation between PTHrP expression and anchorage-independent cell growth. PTHrP significantly increased xenograft growth; tumors from PTHrP-overexpressing cells showed increased expression of integrins α6 and β4, and PI3-K pathway components. The higher expression of PTHrP in human colon cancer adenocarcinoma vs. normal colonic mucosa was accompanied by increased integrin α6 and β4 levels. Elevated PTHrP expression in colon cancer may thus upregulate integrin α6β4 expression, with consequent PI3-K activation. Targeting PTHrP might result in effective inhibition of tumor growth, migration, and invasion.

KW - Colon cancer

KW - Integrin α6β4

KW - Phosphatidylinositol 3-kinase

KW - PTHrP

UR - http://www.scopus.com/inward/record.url?scp=36049009987&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36049009987&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2007.09.010

DO - 10.1016/j.canlet.2007.09.010

M3 - Article

C2 - 17964713

AN - SCOPUS:36049009987

VL - 258

SP - 241

EP - 252

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 2

ER -