Pulmonary artery wedge pressure may fail to reflect left ventricular end-diastolic pressure in dogs with oleic acid-induced pulmonary edema

W. E. Johnston, Donald Prough, R. L. Royster, G. Howard, J. C. Johnson, B. D. McLees

Research output: Contribution to journalArticle

Abstract

We investigated the accuracy with which pulmonary artery wedge pressure (WP) reflected left ventricular end-diastolic pressure (LVEDP) in dogs with oleic acid-induced pulmonary edema. We compared hemodynamic variables before and during edema, as measured from a pulmonary artery catheter placed before oleic acid (PA-1) and from a second catheter (PA-2) placed 2 h after oleic acid infusion. Oleic acid decreased arterial oxygen saturation and cardiac output and increased pulmonary vascular resistance and phasic pulmonary artery pressure. LVEDP did not change after oleic acid, although WP measured by both catheters was increased. In addition, WP measured by PA-2 (7.1 ± 0.7 mm Hg) was greater than that measured by PA-1 (5.6 ± 0.5 mm Hg) (p ≤ 0.037). Using PA-1, we found that WP increased in a linear manner with LVEDP both before and after pulmonary injury (r2 = 0.91, 0.68, respectively). There was no relationship between LVEDP and WP using PA-2 (r2 = 0.07). We conclude that oleic acid-induced pulmonary edema lessens the accuracy with which WP reflects LVEDP, and that WP from a catheter placed after edema less accurately reflects LVEDP than does WP from a catheter placed before edema.

Original languageEnglish (US)
Pages (from-to)487-491
Number of pages5
JournalCritical Care Medicine
Volume13
Issue number6
StatePublished - 1985
Externally publishedYes

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Pulmonary Wedge Pressure
Pulmonary Edema
Oleic Acid
Dogs
Blood Pressure
Catheters
Edema
Pulmonary Artery
Lung Injury
Cardiac Output
Vascular Resistance
Hemodynamics
Oxygen
Pressure

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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Pulmonary artery wedge pressure may fail to reflect left ventricular end-diastolic pressure in dogs with oleic acid-induced pulmonary edema. / Johnston, W. E.; Prough, Donald; Royster, R. L.; Howard, G.; Johnson, J. C.; McLees, B. D.

In: Critical Care Medicine, Vol. 13, No. 6, 1985, p. 487-491.

Research output: Contribution to journalArticle

Johnston, W. E. ; Prough, Donald ; Royster, R. L. ; Howard, G. ; Johnson, J. C. ; McLees, B. D. / Pulmonary artery wedge pressure may fail to reflect left ventricular end-diastolic pressure in dogs with oleic acid-induced pulmonary edema. In: Critical Care Medicine. 1985 ; Vol. 13, No. 6. pp. 487-491.
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