Pulmonary blood flow regulation: Influence of positive pressure ventilation

J. L. Theissen; S. R. Fischer; L. D. Traber; D. L. Traber

doi:10.1016/0034-5687(95)00049-6

Pulmonary blood flow regulation: Influence of positive pressure ventilation

J. L. Theissen, S. R. Fischer, L. D. Traber, D. L. Traber

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Positive pressure ventilation with PEEP has been reported to reduce hypoxic pulmonary vasoconstriction (HPV) and thus increase venous admixture. This effect was investigated in six chronically instrumented unanesthetized healthy sheep. The change in left pulmonary arterial blood flow (Q̇lpa, ultrasonic transit time) in response to unilateral lung hypoxia (10 min of N₂ alternately to the left (LLH) and right lung (RLH)) was evaluated during mechanical ventilation with and without PEEP of 10 cm H₂O in comparison to spontaneous breathing. In the spontaneously breathing animal and during mechanical ventilation without PEEP, Q̇lpa decreased during LLH from 30% to 16% of cardiac index, during RLH it increased to 51%. With 10 cm H₂O of PEEP, Q̇lpa showed an identical reaction to hypoxia both in the left and right lung. It is concluded that mechanical ventilation and PEEP up to 10 cm H₂O does not interfere with pulmonary blood flow regulation to hypoxia.

Original language	English (US)
Pages (from-to)	251-260
Number of pages	10
Journal	Respiration Physiology
Volume	102
Issue number	2-3
DOIs	https://doi.org/10.1016/0034-5687(95)00049-6
State	Published - Dec 1995
Externally published	Yes

Keywords

Blood flow, pulmonary artery
Hypoxia, pulmonary vasoconstriction
Hypoxic pulmonary vasoconstriction
Mammals, sheep
PEEP
Positive pressure ventilation

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine

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10.1016/0034-5687(95)00049-6

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title = "Pulmonary blood flow regulation: Influence of positive pressure ventilation",

abstract = "Positive pressure ventilation with PEEP has been reported to reduce hypoxic pulmonary vasoconstriction (HPV) and thus increase venous admixture. This effect was investigated in six chronically instrumented unanesthetized healthy sheep. The change in left pulmonary arterial blood flow ({\.Q}lpa, ultrasonic transit time) in response to unilateral lung hypoxia (10 min of N2 alternately to the left (LLH) and right lung (RLH)) was evaluated during mechanical ventilation with and without PEEP of 10 cm H2O in comparison to spontaneous breathing. In the spontaneously breathing animal and during mechanical ventilation without PEEP, {\.Q}lpa decreased during LLH from 30% to 16% of cardiac index, during RLH it increased to 51%. With 10 cm H2O of PEEP, {\.Q}lpa showed an identical reaction to hypoxia both in the left and right lung. It is concluded that mechanical ventilation and PEEP up to 10 cm H2O does not interfere with pulmonary blood flow regulation to hypoxia.",

keywords = "Blood flow, pulmonary artery, Hypoxia, pulmonary vasoconstriction, Hypoxic pulmonary vasoconstriction, Mammals, sheep, PEEP, Positive pressure ventilation",

author = "Theissen, {J. L.} and Fischer, {S. R.} and Traber, {L. D.} and Traber, {D. L.}",

note = "Funding Information: This project was supported in part by Grant GM33324 from the National Institute of General Medical Sciences and SNA15845 from the Shriners of North America.",

year = "1995",

month = dec,

doi = "10.1016/0034-5687(95)00049-6",

language = "English (US)",

volume = "102",

pages = "251--260",

journal = "Respiration Physiology",

issn = "0034-5687",

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T2 - Influence of positive pressure ventilation

AU - Theissen, J. L.

AU - Fischer, S. R.

AU - Traber, L. D.

AU - Traber, D. L.

N1 - Funding Information: This project was supported in part by Grant GM33324 from the National Institute of General Medical Sciences and SNA15845 from the Shriners of North America.

PY - 1995/12

Y1 - 1995/12

N2 - Positive pressure ventilation with PEEP has been reported to reduce hypoxic pulmonary vasoconstriction (HPV) and thus increase venous admixture. This effect was investigated in six chronically instrumented unanesthetized healthy sheep. The change in left pulmonary arterial blood flow (Q̇lpa, ultrasonic transit time) in response to unilateral lung hypoxia (10 min of N2 alternately to the left (LLH) and right lung (RLH)) was evaluated during mechanical ventilation with and without PEEP of 10 cm H2O in comparison to spontaneous breathing. In the spontaneously breathing animal and during mechanical ventilation without PEEP, Q̇lpa decreased during LLH from 30% to 16% of cardiac index, during RLH it increased to 51%. With 10 cm H2O of PEEP, Q̇lpa showed an identical reaction to hypoxia both in the left and right lung. It is concluded that mechanical ventilation and PEEP up to 10 cm H2O does not interfere with pulmonary blood flow regulation to hypoxia.

AB - Positive pressure ventilation with PEEP has been reported to reduce hypoxic pulmonary vasoconstriction (HPV) and thus increase venous admixture. This effect was investigated in six chronically instrumented unanesthetized healthy sheep. The change in left pulmonary arterial blood flow (Q̇lpa, ultrasonic transit time) in response to unilateral lung hypoxia (10 min of N2 alternately to the left (LLH) and right lung (RLH)) was evaluated during mechanical ventilation with and without PEEP of 10 cm H2O in comparison to spontaneous breathing. In the spontaneously breathing animal and during mechanical ventilation without PEEP, Q̇lpa decreased during LLH from 30% to 16% of cardiac index, during RLH it increased to 51%. With 10 cm H2O of PEEP, Q̇lpa showed an identical reaction to hypoxia both in the left and right lung. It is concluded that mechanical ventilation and PEEP up to 10 cm H2O does not interfere with pulmonary blood flow regulation to hypoxia.

KW - Blood flow, pulmonary artery

KW - Hypoxia, pulmonary vasoconstriction

KW - Hypoxic pulmonary vasoconstriction

KW - Mammals, sheep

KW - PEEP

KW - Positive pressure ventilation

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Pulmonary blood flow regulation: Influence of positive pressure ventilation

Abstract

Keywords

ASJC Scopus subject areas

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