Pulmonary injury complicating antepartum pyelonephritis

F. Gary Cunningham, Michael J. Lucas, Gary Hankins

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Over a 7-year period, 15 pregnant women admitted to Parkland Memorial Hospital for acute pyelonephritis developed respiratory insufficiency characterized by dyspnea, tachypnea, hypoxemia, and radiographic evidence of pulmonary infiltrates. Clinical manifestations usually appeared 24 to 48 hours after the patient was admitted and varied from mild respiratory distress to pulmonary failure in three; these three required tracheal intubation and mechanical ventilation. We found no evidence that pulmonary edema was caused by intravenous fluid overload. Oxygen therapy and ventilation were given to maintain the arterial Po2 at 80 mm Hg or greater, and erythrocyte transfusions were given to six women to correct anemia. Women with pulmonary injury were more likely to have multisystem derangement than a control group without respiratory involvement, but there were no clinical risk factors that were predictive at admission. This syndrome was probably caused by permeability pulmonary edema, likely mediated by endotoxin-induced alveolar-capillary membrane injury since other evidence of endotoxemia was common. Thrombocytopenia, hymolysis, intravascular coagulation, renal dysfunction, and transient cardiomegaly concomitant with hyperdynamic ventricular function are all explicable from endotoxin effects.

Original languageEnglish (US)
Pages (from-to)797-807
Number of pages11
JournalAmerican Journal of Obstetrics and Gynecology
Volume156
Issue number4
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Pyelonephritis
Lung Injury
Pulmonary Edema
Endotoxins
Tachypnea
Erythrocyte Transfusion
Lung
Endotoxemia
Ventricular Function
Cardiomegaly
Artificial Respiration
Intubation
Respiratory Insufficiency
Thrombocytopenia
Dyspnea
Ventilation
Anemia
Pregnant Women
Permeability
Oxygen

Keywords

  • Pregnancy
  • pulmonary edema
  • pyelonephritis
  • respiratory insufficiency

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Pulmonary injury complicating antepartum pyelonephritis. / Cunningham, F. Gary; Lucas, Michael J.; Hankins, Gary.

In: American Journal of Obstetrics and Gynecology, Vol. 156, No. 4, 1987, p. 797-807.

Research output: Contribution to journalArticle

Cunningham, F. Gary ; Lucas, Michael J. ; Hankins, Gary. / Pulmonary injury complicating antepartum pyelonephritis. In: American Journal of Obstetrics and Gynecology. 1987 ; Vol. 156, No. 4. pp. 797-807.
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