@article{c97fe6c29fed4a7b83eea9f650b97b1f,
title = "Pulmonary involvement during the Ebola virus disease",
abstract = "Filoviruses have become a worldwide public health concern, especially during the 2013–2016 Western Africa Ebola virus disease (EVD) outbreak—the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several organs, including the liver, kidney, and lung. During the 2013–2016 Western Africa outbreak, Ebola virus (EBOV) was detected in the lung of infected patients suggesting a role in lung pathogenesis. However, little is known about lung pathogenesis and the controversial issue of aerosol transmission in EVD. This review highlights the pulmonary involvement in EVD, with a special focus on the new data emerging from the 2013–2016 Ebola outbreak.",
keywords = "Ebola virus, Ebola virus disease, Lung pathogenesis, Respiratory disease",
author = "Eleonora Lalle and Mirella Biava and Emanuele Nicastri and Francesca Colavita and {Di Caro}, Antonino and Francesco Vairo and Simone Lanini and Concetta Castilletti and Martin Langer and Alimuddin Zumla and Gary Kobinger and Capobianchi, {Maria R.} and Giuseppe Ippolito",
note = "Funding Information: This research was funded by the Italian Ministry of Health, grant Ricerca Corrente—linea 1; the European and Developing Countries Clinical Trials Partnership (EDCTP2), PANDORA-ID-NET project, grant number RIA2016E-1609. Acknowledgments: The National Institute for Infectious Diseases, Lazzaro Spallanzani acknowledge support from the Italian Ministry of Health, grants to Ricerca Corrente linea 1. Giuseppe Ippolito, Francesco Vairo, and Alimuddin Zumla are member of the PANDORA-ID-NET consortium grant, funded by the European, and Developing Countries Clinical Trials Partnership (EDCTP2) programme (EDCTP Reg/Grant RIA2016E-1609), which is supported under Horizon 2020, the European Union{\textquoteright}s Framework Programme for Research and Innovation. Giuseppe Ippolito, Antonino Di Caro, Francesco Vairo, Simone Lanini, Gary Kobinger and Alimuddin Zumla are member of the International Public Health Crisis. The Group performs independent analysis and research activities on epidemic and endemic events naturally occurring or related to the deliberate release of pathogens, providing strategic, organizational, educational, logistic support and advice for preparedness and response. Emanuele Nicastri, Antonino Di Caro, Francesco Vairo, Simone Lanini, Maria R. Capobianchi and Giuseppe Ippolito are Professors at Saint Camillus International University of Health Sciences, Rome, Italy. Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2019",
month = sep,
doi = "10.3390/v11090780",
language = "English (US)",
volume = "11",
journal = "Viruses",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "9",
}