Pulmonary involvement during the Ebola virus disease

Eleonora Lalle; Mirella Biava; Emanuele Nicastri; Francesca Colavita; Antonino Di Caro; Francesco Vairo; Simone Lanini; Concetta Castilletti; Martin Langer; Alimuddin Zumla; Gary Kobinger; Maria R. Capobianchi; Giuseppe Ippolito

doi:10.3390/v11090780

Pulmonary involvement during the Ebola virus disease

Eleonora Lalle, Mirella Biava, Emanuele Nicastri, Francesca Colavita, Antonino Di Caro, Francesco Vairo, Simone Lanini, Concetta Castilletti, Martin Langer, Alimuddin Zumla, Gary Kobinger, Maria R. Capobianchi, Giuseppe Ippolito

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Filoviruses have become a worldwide public health concern, especially during the 2013–2016 Western Africa Ebola virus disease (EVD) outbreak—the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several organs, including the liver, kidney, and lung. During the 2013–2016 Western Africa outbreak, Ebola virus (EBOV) was detected in the lung of infected patients suggesting a role in lung pathogenesis. However, little is known about lung pathogenesis and the controversial issue of aerosol transmission in EVD. This review highlights the pulmonary involvement in EVD, with a special focus on the new data emerging from the 2013–2016 Ebola outbreak.

Original language	English (US)
Article number	780
Journal	Viruses
Volume	11
Issue number	9
DOIs	https://doi.org/10.3390/v11090780
State	Published - Sep 2019
Externally published	Yes

Keywords

Ebola virus
Ebola virus disease
Lung pathogenesis
Respiratory disease

ASJC Scopus subject areas

Infectious Diseases
Virology

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10.3390/v11090780

Cite this

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title = "Pulmonary involvement during the Ebola virus disease",

abstract = "Filoviruses have become a worldwide public health concern, especially during the 2013–2016 Western Africa Ebola virus disease (EVD) outbreak—the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several organs, including the liver, kidney, and lung. During the 2013–2016 Western Africa outbreak, Ebola virus (EBOV) was detected in the lung of infected patients suggesting a role in lung pathogenesis. However, little is known about lung pathogenesis and the controversial issue of aerosol transmission in EVD. This review highlights the pulmonary involvement in EVD, with a special focus on the new data emerging from the 2013–2016 Ebola outbreak.",

keywords = "Ebola virus, Ebola virus disease, Lung pathogenesis, Respiratory disease",

author = "Eleonora Lalle and Mirella Biava and Emanuele Nicastri and Francesca Colavita and {Di Caro}, Antonino and Francesco Vairo and Simone Lanini and Concetta Castilletti and Martin Langer and Alimuddin Zumla and Gary Kobinger and Capobianchi, {Maria R.} and Giuseppe Ippolito",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

month = sep,

doi = "10.3390/v11090780",

language = "English (US)",

volume = "11",

journal = "Viruses",

issn = "1999-4915",

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T1 - Pulmonary involvement during the Ebola virus disease

AU - Lalle, Eleonora

AU - Biava, Mirella

AU - Nicastri, Emanuele

AU - Colavita, Francesca

AU - Di Caro, Antonino

AU - Vairo, Francesco

AU - Lanini, Simone

AU - Castilletti, Concetta

AU - Langer, Martin

AU - Zumla, Alimuddin

AU - Kobinger, Gary

AU - Capobianchi, Maria R.

AU - Ippolito, Giuseppe

PY - 2019/9

Y1 - 2019/9

N2 - Filoviruses have become a worldwide public health concern, especially during the 2013–2016 Western Africa Ebola virus disease (EVD) outbreak—the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several organs, including the liver, kidney, and lung. During the 2013–2016 Western Africa outbreak, Ebola virus (EBOV) was detected in the lung of infected patients suggesting a role in lung pathogenesis. However, little is known about lung pathogenesis and the controversial issue of aerosol transmission in EVD. This review highlights the pulmonary involvement in EVD, with a special focus on the new data emerging from the 2013–2016 Ebola outbreak.

AB - Filoviruses have become a worldwide public health concern, especially during the 2013–2016 Western Africa Ebola virus disease (EVD) outbreak—the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several organs, including the liver, kidney, and lung. During the 2013–2016 Western Africa outbreak, Ebola virus (EBOV) was detected in the lung of infected patients suggesting a role in lung pathogenesis. However, little is known about lung pathogenesis and the controversial issue of aerosol transmission in EVD. This review highlights the pulmonary involvement in EVD, with a special focus on the new data emerging from the 2013–2016 Ebola outbreak.

KW - Ebola virus

KW - Ebola virus disease

KW - Lung pathogenesis

KW - Respiratory disease

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U2 - 10.3390/v11090780

DO - 10.3390/v11090780

M3 - Review article

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VL - 11

JO - Viruses

JF - Viruses

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Pulmonary involvement during the Ebola virus disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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