Pulmonary microvascular changes following fluid resuscitation in an ovine model of endotoxemia

H. J. Lubbesmeyer, R. Kimura, J. P. Maguire, M. Irei, L. D. Traber, D. L. Traber, David Herndon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Fluid resuscitation is complicated in hypotensive septic patients by their susceptibility to pulmonary edema. This problem was evaluated in the ovine model of endotoxemia with a chronic lung lymph fistula. Escherichia coli endotoxin (lipopolysaccharide, 1.5 μg/kg) was given intravenously over 30 minutes. Group M (n=9) continued to receive baseline fluids (2 mL/kg/h), while group R (n=6) received 7 mL/kg/h of Ringer's lactate. After an initial drop in cardiac index, animals in both groups developed a hyperdynamic state. The fall in mean arterial pressure seen in group M was absent from group R. The higher fluid volume resulted in a rise in left atrial pressure and pulmonary microvascular pressure. The lung lymph flow and permeability index were evaluated in both groups but were higher in group R. The calculated filtration coefficient showed a threefold increase in both groups. Augmented fluid resuscitation during endotoxemia resulted in an elevated interstitial fluid flux and permeability index secondary to an increase in pulmonary microvascular pressure and greater surface area of the injured microvascular beds being perfused.

Original languageEnglish (US)
Pages (from-to)345-350
Number of pages6
JournalArchives of Surgery
Volume123
Issue number3
StatePublished - 1988

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Endotoxemia
Resuscitation
Sheep
Lung
Lymph
Permeability
Pressure
Atrial Pressure
Extracellular Fluid
Pulmonary Edema
Fistula
Lipopolysaccharides
Arterial Pressure

ASJC Scopus subject areas

  • Surgery

Cite this

Lubbesmeyer, H. J., Kimura, R., Maguire, J. P., Irei, M., Traber, L. D., Traber, D. L., & Herndon, D. (1988). Pulmonary microvascular changes following fluid resuscitation in an ovine model of endotoxemia. Archives of Surgery, 123(3), 345-350.

Pulmonary microvascular changes following fluid resuscitation in an ovine model of endotoxemia. / Lubbesmeyer, H. J.; Kimura, R.; Maguire, J. P.; Irei, M.; Traber, L. D.; Traber, D. L.; Herndon, David.

In: Archives of Surgery, Vol. 123, No. 3, 1988, p. 345-350.

Research output: Contribution to journalArticle

Lubbesmeyer, HJ, Kimura, R, Maguire, JP, Irei, M, Traber, LD, Traber, DL & Herndon, D 1988, 'Pulmonary microvascular changes following fluid resuscitation in an ovine model of endotoxemia', Archives of Surgery, vol. 123, no. 3, pp. 345-350.
Lubbesmeyer HJ, Kimura R, Maguire JP, Irei M, Traber LD, Traber DL et al. Pulmonary microvascular changes following fluid resuscitation in an ovine model of endotoxemia. Archives of Surgery. 1988;123(3):345-350.
Lubbesmeyer, H. J. ; Kimura, R. ; Maguire, J. P. ; Irei, M. ; Traber, L. D. ; Traber, D. L. ; Herndon, David. / Pulmonary microvascular changes following fluid resuscitation in an ovine model of endotoxemia. In: Archives of Surgery. 1988 ; Vol. 123, No. 3. pp. 345-350.
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