Pulmonary transvascular fluid flux and cardiovascular function in sheep with chronic sepsis

H. Nakazawa, H. Noda, S. Noshima, J. T. Flynn, L. D. Traber, David Herndon, D. L. Traber

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We studied the mechanisms responsible for the changes in lung lymph flow (Q̇(L)) in chronic sepsis induced by the continuous infusion of endotoxin [lipopolysaccharide (LPS), 10 ng · kg-1 · min-1]. Sheep (n = 11) were studied in the unanesthetized state 7 days after preparation, and cardiopulmonary variables were measured. In the control group (n = 5) given lactated Ringer solution, no significant changes were observed in any measured variables. In the LPS group (n = 6), Q̇(L) increased from 11.7 ± 3.8 to 54.0 ± 15.0 (SE) ml/h 24 h after LPS infusion had begun. This elevation in Q̇(L) was associated with little or no change (P > 0.05) in reflection coefficient (0.80 ± 0.03 to 0.87 ± 0.05) or pulmonary microvascular pressure (14.3 ± 0.4 to 16.7 ± 1.2 mmHg). The filtration coefficient, however, was significantly elevated (0.018 ± 0.006 to 0.083 ± 0.024 ml · min-1 · mmHg-1). In association with changes in Q̇(L) that occur as a result of LPS administration there was a significant increase in cardiac index (6.1 ± 0.5 to 10.2 ± 0.3 l · min-1 · m-2) and a reduction in mean arterial pressure (90.2 ± 4.4 to 73.7 ± 7.3 mmHg) and systemic vascular resistance index (1,229 ± 134 to 583 ± 62 dyn · s · cm-5 · m2), findings similar to those noted in septic humans.

Original languageEnglish (US)
Pages (from-to)2521-2528
Number of pages8
JournalJournal of Applied Physiology
Volume75
Issue number6
StatePublished - 1993

Fingerprint

Lipopolysaccharides
Sheep
Sepsis
Lung
Lymph
Endotoxins
Vascular Resistance
Arterial Pressure
Pressure
Control Groups

Keywords

  • blood pressure
  • cardiac output
  • endotoxins
  • filtration coefficient
  • lung lymph flow
  • pulmonary capillary pressure
  • reflection coefficient

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Nakazawa, H., Noda, H., Noshima, S., Flynn, J. T., Traber, L. D., Herndon, D., & Traber, D. L. (1993). Pulmonary transvascular fluid flux and cardiovascular function in sheep with chronic sepsis. Journal of Applied Physiology, 75(6), 2521-2528.

Pulmonary transvascular fluid flux and cardiovascular function in sheep with chronic sepsis. / Nakazawa, H.; Noda, H.; Noshima, S.; Flynn, J. T.; Traber, L. D.; Herndon, David; Traber, D. L.

In: Journal of Applied Physiology, Vol. 75, No. 6, 1993, p. 2521-2528.

Research output: Contribution to journalArticle

Nakazawa, H, Noda, H, Noshima, S, Flynn, JT, Traber, LD, Herndon, D & Traber, DL 1993, 'Pulmonary transvascular fluid flux and cardiovascular function in sheep with chronic sepsis', Journal of Applied Physiology, vol. 75, no. 6, pp. 2521-2528.
Nakazawa H, Noda H, Noshima S, Flynn JT, Traber LD, Herndon D et al. Pulmonary transvascular fluid flux and cardiovascular function in sheep with chronic sepsis. Journal of Applied Physiology. 1993;75(6):2521-2528.
Nakazawa, H. ; Noda, H. ; Noshima, S. ; Flynn, J. T. ; Traber, L. D. ; Herndon, David ; Traber, D. L. / Pulmonary transvascular fluid flux and cardiovascular function in sheep with chronic sepsis. In: Journal of Applied Physiology. 1993 ; Vol. 75, No. 6. pp. 2521-2528.
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