Abstract
We studied the mechanisms responsible for the changes in lung lymph flow (Q̇(L)) in chronic sepsis induced by the continuous infusion of endotoxin [lipopolysaccharide (LPS), 10 ng · kg-1 · min-1]. Sheep (n = 11) were studied in the unanesthetized state 7 days after preparation, and cardiopulmonary variables were measured. In the control group (n = 5) given lactated Ringer solution, no significant changes were observed in any measured variables. In the LPS group (n = 6), Q̇(L) increased from 11.7 ± 3.8 to 54.0 ± 15.0 (SE) ml/h 24 h after LPS infusion had begun. This elevation in Q̇(L) was associated with little or no change (P > 0.05) in reflection coefficient (0.80 ± 0.03 to 0.87 ± 0.05) or pulmonary microvascular pressure (14.3 ± 0.4 to 16.7 ± 1.2 mmHg). The filtration coefficient, however, was significantly elevated (0.018 ± 0.006 to 0.083 ± 0.024 ml · min-1 · mmHg-1). In association with changes in Q̇(L) that occur as a result of LPS administration there was a significant increase in cardiac index (6.1 ± 0.5 to 10.2 ± 0.3 l · min-1 · m-2) and a reduction in mean arterial pressure (90.2 ± 4.4 to 73.7 ± 7.3 mmHg) and systemic vascular resistance index (1,229 ± 134 to 583 ± 62 dyn · s · cm-5 · m2), findings similar to those noted in septic humans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2521-2528 |
| Number of pages | 8 |
| Journal | Journal of Applied Physiology |
| Volume | 75 |
| Issue number | 6 |
| State | Published - 1993 |
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Keywords
- blood pressure
- cardiac output
- endotoxins
- filtration coefficient
- lung lymph flow
- pulmonary capillary pressure
- reflection coefficient
ASJC Scopus subject areas
- Endocrinology
- Physiology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Pulmonary transvascular fluid flux and cardiovascular function in sheep with chronic sepsis. / Nakazawa, H.; Noda, H.; Noshima, S.; Flynn, J. T.; Traber, L. D.; Herndon, David; Traber, D. L.
In: Journal of Applied Physiology, Vol. 75, No. 6, 1993, p. 2521-2528.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pulmonary transvascular fluid flux and cardiovascular function in sheep with chronic sepsis
AU - Nakazawa, H.
AU - Noda, H.
AU - Noshima, S.
AU - Flynn, J. T.
AU - Traber, L. D.
AU - Herndon, David
AU - Traber, D. L.
PY - 1993
Y1 - 1993
N2 - We studied the mechanisms responsible for the changes in lung lymph flow (Q̇(L)) in chronic sepsis induced by the continuous infusion of endotoxin [lipopolysaccharide (LPS), 10 ng · kg-1 · min-1]. Sheep (n = 11) were studied in the unanesthetized state 7 days after preparation, and cardiopulmonary variables were measured. In the control group (n = 5) given lactated Ringer solution, no significant changes were observed in any measured variables. In the LPS group (n = 6), Q̇(L) increased from 11.7 ± 3.8 to 54.0 ± 15.0 (SE) ml/h 24 h after LPS infusion had begun. This elevation in Q̇(L) was associated with little or no change (P > 0.05) in reflection coefficient (0.80 ± 0.03 to 0.87 ± 0.05) or pulmonary microvascular pressure (14.3 ± 0.4 to 16.7 ± 1.2 mmHg). The filtration coefficient, however, was significantly elevated (0.018 ± 0.006 to 0.083 ± 0.024 ml · min-1 · mmHg-1). In association with changes in Q̇(L) that occur as a result of LPS administration there was a significant increase in cardiac index (6.1 ± 0.5 to 10.2 ± 0.3 l · min-1 · m-2) and a reduction in mean arterial pressure (90.2 ± 4.4 to 73.7 ± 7.3 mmHg) and systemic vascular resistance index (1,229 ± 134 to 583 ± 62 dyn · s · cm-5 · m2), findings similar to those noted in septic humans.
AB - We studied the mechanisms responsible for the changes in lung lymph flow (Q̇(L)) in chronic sepsis induced by the continuous infusion of endotoxin [lipopolysaccharide (LPS), 10 ng · kg-1 · min-1]. Sheep (n = 11) were studied in the unanesthetized state 7 days after preparation, and cardiopulmonary variables were measured. In the control group (n = 5) given lactated Ringer solution, no significant changes were observed in any measured variables. In the LPS group (n = 6), Q̇(L) increased from 11.7 ± 3.8 to 54.0 ± 15.0 (SE) ml/h 24 h after LPS infusion had begun. This elevation in Q̇(L) was associated with little or no change (P > 0.05) in reflection coefficient (0.80 ± 0.03 to 0.87 ± 0.05) or pulmonary microvascular pressure (14.3 ± 0.4 to 16.7 ± 1.2 mmHg). The filtration coefficient, however, was significantly elevated (0.018 ± 0.006 to 0.083 ± 0.024 ml · min-1 · mmHg-1). In association with changes in Q̇(L) that occur as a result of LPS administration there was a significant increase in cardiac index (6.1 ± 0.5 to 10.2 ± 0.3 l · min-1 · m-2) and a reduction in mean arterial pressure (90.2 ± 4.4 to 73.7 ± 7.3 mmHg) and systemic vascular resistance index (1,229 ± 134 to 583 ± 62 dyn · s · cm-5 · m2), findings similar to those noted in septic humans.
KW - blood pressure
KW - cardiac output
KW - endotoxins
KW - filtration coefficient
KW - lung lymph flow
KW - pulmonary capillary pressure
KW - reflection coefficient
UR - http://www.scopus.com/inward/record.url?scp=0027724268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027724268&partnerID=8YFLogxK
M3 - Article
VL - 75
SP - 2521
EP - 2528
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 6
ER -