Richard D. Kane, Hal K. Hawkins, James A. Miller, Peter S. Noce

Research output: Contribution to journalArticlepeer-review

207 Scopus citations


A syndrome is described in which severe, clinically unexplained dyspnea is found at autopsy to be caused by multiple microscopic tumor emboli. Such a situation was found in 8 of 16 cases of multiple microscopic tumor emboli in the pulmonary arteries without significant lymphatic or parenchymal involvement of the lungs. The origins of tumor emboli included carcinomas of the prostate, breast, stomach, pancreas, and liver. In the 8 cases that presented with unexplained dyspnea, initial physical, roentgenographic, and electro‐cardiographic examinations were not diagnostic. Clinical or morphological evidence of cor pulmonale was present in only 5 of these 8 cases. The tumor emboli did not invade the walls of pulmonary vessels but were frequently associated with thrombi. Recognition of this clinicopathologic entity becomes important as progress is made in cancer therapy.

Original languageEnglish (US)
Pages (from-to)1473-1482
Number of pages10
Issue number4
StatePublished - Oct 1975
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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