Purification and crystallization of intact human rhinovirus complexed with a neutralizing fab

Thomas James Smith, Elaine S. Chase

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We report the first crystallization of an intact virion, human rhinovirus 14, complexed with the Fab fragment from a neutralizing antibody. These crystals diffract to at least 6.0 Å resolution. It has been suggested that Fab's and mAb's can induce large conformational changes in the capsid upon binding. The structure of this complex should enable us to detect the existence and role of such changes.

Original languageEnglish (US)
Pages (from-to)600-606
Number of pages7
JournalVirology
Volume191
Issue number2
DOIs
StatePublished - Dec 1992
Externally publishedYes

ASJC Scopus subject areas

  • Virology

Fingerprint Dive into the research topics of 'Purification and crystallization of intact human rhinovirus complexed with a neutralizing fab'. Together they form a unique fingerprint.

  • Cite this