Purification and crystallization of intact human rhinovirus complexed with a neutralizing fab

Thomas Smith, Elaine S. Chase

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We report the first crystallization of an intact virion, human rhinovirus 14, complexed with the Fab fragment from a neutralizing antibody. These crystals diffract to at least 6.0 Å resolution. It has been suggested that Fab's and mAb's can induce large conformational changes in the capsid upon binding. The structure of this complex should enable us to detect the existence and role of such changes.

Original languageEnglish (US)
Pages (from-to)600-606
Number of pages7
JournalVirology
Volume191
Issue number2
DOIs
StatePublished - 1992
Externally publishedYes

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ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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