Purpura fulminans and late onset group B streptococcal sepsis in a premature twin

Avanikkha Elayappen, Sunil Jain, Michael J. Loeffelholz, Janak Patel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: Purpura fulminans (PF) is a skin manifestation due to hemorrhagic infarction caused by intravascular thrombosis secondary to bacterial infections or deficiency of anticoagulants such as protein C and protein S. Neonatal PF is a rare but potentially disabling disorder associated with a high mortality and severe long term morbidity in those who survive. Case description: We report a case of a premature infant who developed extensive PF due to late onset group B streptococcus sepsis. Despite early identification and initiation of antibiotic therapy in our patient, PF progressed rapidly, leading to autoamputation of fingers and toes and severe brain injury. Conclusion: In conclusion, our case highlights the severe sequelae of PF due to late onset GBS sepsis in a premature infant.

Original languageEnglish (US)
Pages (from-to)e69-e72
JournalAJP Reports
Volume4
Issue number2
DOIs
StatePublished - May 12 2014

Fingerprint

Purpura Fulminans
Sepsis
Premature Infants
Skin Manifestations
Streptococcus agalactiae
Protein S
Toes
Protein C
Bacterial Infections
Anticoagulants
Brain Injuries
Infarction
Fingers
Thrombosis
Anti-Bacterial Agents
Morbidity
Mortality

Keywords

  • coagulation
  • GBS
  • meningitis
  • neonate
  • purpura fulminans
  • serotype Ia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Purpura fulminans and late onset group B streptococcal sepsis in a premature twin. / Elayappen, Avanikkha; Jain, Sunil; Loeffelholz, Michael J.; Patel, Janak.

In: AJP Reports, Vol. 4, No. 2, 12.05.2014, p. e69-e72.

Research output: Contribution to journalArticle

Elayappen, Avanikkha ; Jain, Sunil ; Loeffelholz, Michael J. ; Patel, Janak. / Purpura fulminans and late onset group B streptococcal sepsis in a premature twin. In: AJP Reports. 2014 ; Vol. 4, No. 2. pp. e69-e72.
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