Puumala virus and two genetic variants of Tula virus are present in Austrian rodents

Michael D. Bowen, Wolfgang Gelbmann, Thomas Ksiazek, Stuart T. Nichol, Norbert Nowotny

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Puumala and Tula viruses are hantaviruses found in Europe and are associated with the rodents Clethrionomys glareolus and Microtus arvalis, respectively. Puumala virus is associated with the human disease nephropathia epidemica. In Austria, ten clinically diagnosed cases of nephropathia epidemica, presumably caused by Puumala virus infection, have been reported but not virologically confirmed [Leschinskaya et al., 1991; Aberle et al., 1996]. To identify the hantaviruses that are present in Austria, five species of rodents were trapped and screened for virus antibodies, antigen, and RNA. Hantaviruses were detected in two species, Cl. glareolus and M. arvalis, by reverse transcription-polymerase chain reaction (RT-PCR). RT-PCR products from Cl. glareolus tissues yielded a unique Puumala virus sequence distinct from Puumala virus sequences reported from other parts of Europe. RT-PCR products from M. arvalis tissues yielded two genetically distinct Tula virus sequences, one similar to sequences reported from Slovakia and the Czech Republic and another that appears to be a novel genetic variant of Tula virus. This is the first confirmed report of hantaviruses in Austria.

Original languageEnglish (US)
Pages (from-to)174-181
Number of pages8
JournalJournal of Medical Virology
Volume53
Issue number2
DOIs
StatePublished - Oct 1997
Externally publishedYes

Fingerprint

Puumala virus
Hantavirus
Rodentia
Austria
Viruses
Reverse Transcription
Hemorrhagic Fever with Renal Syndrome
Arvicolinae
Polymerase Chain Reaction
Slovakia
Czech Republic
Virus Diseases
RNA
Antigens
Antibodies

Keywords

  • Bunyaviridae
  • Clethrionomys glareolus
  • Hantavirus
  • Microtus arvalis
  • PCR

ASJC Scopus subject areas

  • Virology

Cite this

Puumala virus and two genetic variants of Tula virus are present in Austrian rodents. / Bowen, Michael D.; Gelbmann, Wolfgang; Ksiazek, Thomas; Nichol, Stuart T.; Nowotny, Norbert.

In: Journal of Medical Virology, Vol. 53, No. 2, 10.1997, p. 174-181.

Research output: Contribution to journalArticle

Bowen, Michael D. ; Gelbmann, Wolfgang ; Ksiazek, Thomas ; Nichol, Stuart T. ; Nowotny, Norbert. / Puumala virus and two genetic variants of Tula virus are present in Austrian rodents. In: Journal of Medical Virology. 1997 ; Vol. 53, No. 2. pp. 174-181.
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