In cultured fibroblasts, a mutation resulting in deficiency of a pyrimidine salvage enzyme leads to excretion of related pyrimidines. For example, absence of thymidine kinase led to loss of thymidine and deoxyuridine, and absence of deoxycytidine kinase to loss of deoxyuridine. Both wild type and mutant cells excreted uracil; if established lines are representative in this respect, a fully adequate salvage system for uracil does not seem to be present in the fibroblast.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Cellular Physiology|
|State||Published - 1974|
ASJC Scopus subject areas
- Cell Biology
- Clinical Biochemistry