Pyrimidine starvation induced by adenosine in fibroblasts and lymphoid cells: Role of adenosine deaminase

Howard Green, Teh Sheng Chan

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

In the presence of 10-4 to 10-5 molar adenosine, established cell lines of fibroblastic or lymphoid origin die of pyrimidine starvation. Less than lethal concentrations inhibit cell growth. Over a broad concentration range, the effects of adenosine are prevented by providing a suitable pyrimidine source. We suggest that the recently described immune deficiency disease associated with absence of adenosine deaminase may be the result of pyrimidine starvation induced by adenosine nucleotides in cells of the lymphoid system.

Original languageEnglish (US)
Pages (from-to)836-837
Number of pages2
JournalScience
Volume182
Issue number4114
StatePublished - 1973
Externally publishedYes

Fingerprint

Adenosine Deaminase
Starvation
Adenosine
Fibroblasts
Lymphocytes
Nucleotides
Cell Line
Growth
pyrimidine

ASJC Scopus subject areas

  • General

Cite this

Pyrimidine starvation induced by adenosine in fibroblasts and lymphoid cells : Role of adenosine deaminase. / Green, Howard; Chan, Teh Sheng.

In: Science, Vol. 182, No. 4114, 1973, p. 836-837.

Research output: Contribution to journalArticle

Green, Howard ; Chan, Teh Sheng. / Pyrimidine starvation induced by adenosine in fibroblasts and lymphoid cells : Role of adenosine deaminase. In: Science. 1973 ; Vol. 182, No. 4114. pp. 836-837.
@article{3b16435a776847fba93e1f0b338f8f55,
title = "Pyrimidine starvation induced by adenosine in fibroblasts and lymphoid cells: Role of adenosine deaminase",
abstract = "In the presence of 10-4 to 10-5 molar adenosine, established cell lines of fibroblastic or lymphoid origin die of pyrimidine starvation. Less than lethal concentrations inhibit cell growth. Over a broad concentration range, the effects of adenosine are prevented by providing a suitable pyrimidine source. We suggest that the recently described immune deficiency disease associated with absence of adenosine deaminase may be the result of pyrimidine starvation induced by adenosine nucleotides in cells of the lymphoid system.",
author = "Howard Green and Chan, {Teh Sheng}",
year = "1973",
language = "English (US)",
volume = "182",
pages = "836--837",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4114",

}

TY - JOUR

T1 - Pyrimidine starvation induced by adenosine in fibroblasts and lymphoid cells

T2 - Role of adenosine deaminase

AU - Green, Howard

AU - Chan, Teh Sheng

PY - 1973

Y1 - 1973

N2 - In the presence of 10-4 to 10-5 molar adenosine, established cell lines of fibroblastic or lymphoid origin die of pyrimidine starvation. Less than lethal concentrations inhibit cell growth. Over a broad concentration range, the effects of adenosine are prevented by providing a suitable pyrimidine source. We suggest that the recently described immune deficiency disease associated with absence of adenosine deaminase may be the result of pyrimidine starvation induced by adenosine nucleotides in cells of the lymphoid system.

AB - In the presence of 10-4 to 10-5 molar adenosine, established cell lines of fibroblastic or lymphoid origin die of pyrimidine starvation. Less than lethal concentrations inhibit cell growth. Over a broad concentration range, the effects of adenosine are prevented by providing a suitable pyrimidine source. We suggest that the recently described immune deficiency disease associated with absence of adenosine deaminase may be the result of pyrimidine starvation induced by adenosine nucleotides in cells of the lymphoid system.

UR - http://www.scopus.com/inward/record.url?scp=0015934047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015934047&partnerID=8YFLogxK

M3 - Article

C2 - 4795749

AN - SCOPUS:0015934047

VL - 182

SP - 836

EP - 837

JO - Science

JF - Science

SN - 0036-8075

IS - 4114

ER -