Pyrimidine starvation induced by adenosine in fibroblasts and lymphoid cells: Role of adenosine deaminase

Howard Green, Teh Sheng Chan

Research output: Contribution to journalArticlepeer-review

184 Scopus citations

Abstract

In the presence of 10-4 to 10-5 molar adenosine, established cell lines of fibroblastic or lymphoid origin die of pyrimidine starvation. Less than lethal concentrations inhibit cell growth. Over a broad concentration range, the effects of adenosine are prevented by providing a suitable pyrimidine source. We suggest that the recently described immune deficiency disease associated with absence of adenosine deaminase may be the result of pyrimidine starvation induced by adenosine nucleotides in cells of the lymphoid system.

Original languageEnglish (US)
Pages (from-to)836-837
Number of pages2
JournalScience
Volume182
Issue number4114
DOIs
StatePublished - Jan 1 1973

ASJC Scopus subject areas

  • General

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