Pyrosequencing of the genital microbiotas of HIV-seropositive and -seronegative women reveals lactobacillus iners as the predominant lactobacillus species

Gregory T. Spear; Douglas Gilbert; Alan L. Landay; Reza Zariffard; Audrey L. French; Pranjal Patel; Patrick M. Gillevet

doi:10.1128/AEM.00973-10

Pyrosequencing of the genital microbiotas of HIV-seropositive and -seronegative women reveals lactobacillus iners as the predominant lactobacillus species

Gregory T. Spear, Douglas Gilbert, Alan L. Landay, Reza Zariffard, Audrey L. French, Pranjal Patel, Patrick M. Gillevet

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The species of vaginal lactobacilli in HIV-seropositive and -seronegative women were determined by 16S gene pyrosequencing. Lactobacillus iners sequences were the predominant lactobacillus sequences in 66% of HIV⁺women and 90% of HIV^- women. This has implications for resistance of HIV ⁺ and HIV^- women to genital colonization by pathogenic organisms.

Original language	English (US)
Pages (from-to)	378-381
Number of pages	4
Journal	Applied and Environmental Microbiology
Volume	77
Issue number	1
DOIs	https://doi.org/10.1128/AEM.00973-10
State	Published - Jan 2011
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology
Ecology

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abstract = "The species of vaginal lactobacilli in HIV-seropositive and -seronegative women were determined by 16S gene pyrosequencing. Lactobacillus iners sequences were the predominant lactobacillus sequences in 66\% of HIV+women and 90\% of HIV- women. This has implications for resistance of HIV + and HIV- women to genital colonization by pathogenic organisms.",

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AU - Landay, Alan L.

AU - Zariffard, Reza

AU - French, Audrey L.

AU - Patel, Pranjal

AU - Gillevet, Patrick M.

PY - 2011/1

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N2 - The species of vaginal lactobacilli in HIV-seropositive and -seronegative women were determined by 16S gene pyrosequencing. Lactobacillus iners sequences were the predominant lactobacillus sequences in 66% of HIV+women and 90% of HIV- women. This has implications for resistance of HIV + and HIV- women to genital colonization by pathogenic organisms.

AB - The species of vaginal lactobacilli in HIV-seropositive and -seronegative women were determined by 16S gene pyrosequencing. Lactobacillus iners sequences were the predominant lactobacillus sequences in 66% of HIV+women and 90% of HIV- women. This has implications for resistance of HIV + and HIV- women to genital colonization by pathogenic organisms.

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Pyrosequencing of the genital microbiotas of HIV-seropositive and -seronegative women reveals lactobacillus iners as the predominant lactobacillus species

Abstract

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