Q50, an iron-chelating and zinc-complexing agent, improves cardiac function in rat models of ischemia/reperfusion-induced myocardial injury

Sevil Korkmaz, Eniko Barnucz, Sivakkanan Loganathan, Shiliang Li, Tamás Radovits, Péter Hegedus, Alina Zubarevich, Kristóf Hirschberg, Alexander Weymann, László G. Puskás, Béla Ózsvári, Nóra Faragó, Iván Kanizsai, Gabriella Fábián, Márió Gyuris, Béla Merkely, Matthias Karck, Csaba Szabó, Gábor Szabó

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    6 Scopus citations

    Abstract

    Background: Reperfusion of ischemic myocardium may contribute to substantial cardiac tissue damage, but the addition of iron chelators, zinc or zinc complexes has been shown to prevent heart from reperfusion injury. We investigated the possible beneficial effects of an iron-chelating and zinc-complexing agent, Q50, in rat models of ischemia/reperfusion (I/R)-induced myocardial infarction and on global reversible myocardial I/R injury after heart transplantation. Methods and Results: Rats underwent 45-min myocardial ischemia by left anterior descending coronary artery ligation followed by 24 h reperfusion. Vehicle or Q50 (10 mg/kg, IV) were given 5 min before reperfusion. In a heart transplantation model, donor rats received vehicle or Q50 (30 mg/kg, IV) 1 h before the onset of ischemia. In myocardial infarcted rats, increased left ventricular end-systolic and end-diastolic volumes were significantly decreased by Q50 post treatment as compared with the sham group. Moreover, in I/R rat hearts, the decreased dP/dtmax and load-independent contractility parameters were significantly increased after Q50. However, Q50 treatment did not reduce infarct size or have any effect on increased plasma cardiac troponin-T-levels. In the rat model of heart transplantation, 1 h after reperfusion, decreased left ventricular systolic pressure, dP/dtmax, dP/dtmin and myocardial ATP content were significantly increased and myocardial protein expression of superoxide dismutase-1 was upregulated after Q50 treatment. Conclusions: In 2 experimental models of I/R, administration of Q50 improved myocardial function. Its mechanisms of action implicate in part the restoration of myocardial high-energy phosphates and upregulation of antioxidant enzymes. (Circ J 2013; 77: 1817 - 1826).

    Original languageEnglish (US)
    Pages (from-to)1817-1826
    Number of pages10
    JournalCirculation Journal
    Volume77
    Issue number7
    DOIs
    StatePublished - 2013

    Keywords

    • Antioxidants
    • Ischemia/reperfusion
    • Myocardial infarction
    • Transplantation

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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    Korkmaz, S., Barnucz, E., Loganathan, S., Li, S., Radovits, T., Hegedus, P., Zubarevich, A., Hirschberg, K., Weymann, A., Puskás, L. G., Ózsvári, B., Faragó, N., Kanizsai, I., Fábián, G., Gyuris, M., Merkely, B., Karck, M., Szabó, C., & Szabó, G. (2013). Q50, an iron-chelating and zinc-complexing agent, improves cardiac function in rat models of ischemia/reperfusion-induced myocardial injury. Circulation Journal, 77(7), 1817-1826. https://doi.org/10.1253/circj.CJ-12-1162