Quality of life improves within 30 days of surgery for Crohn's disease

Conor P. Delaney, Ravi P. Kiran, Anthony J. Senagore, Bridget O'Brien-Ermlich, James Church, Tracy L. Hull, Feza H. Remzi, Victor W. Fazio

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: The effect of surgery on quality of life (QOL) in the early postoperative period is important in Crohn's disease because of the multiple surgical procedures that patients undergo and the acute QOL benefits that might occur as a result of modifications of medical treatment. Earlier studies of the effect of surgery on QOL have been retrospective and assessed changes 3 to 24 months after surgery. This study prospectively assesses the effect of surgery on QOL in the early postoperative period. STUDY DESIGN: Patients requiring surgical management of sequelae of Crohn's disease were obtained from a prospectively entered database including data on QOL. Preoperative and 30-day postoperative QOL were determined in 82 patients using Cleveland Global Quality of Life (CGQL) scores (range from 0 [worst] to 10 [best possible] QOL). Preoperative and postoperative scores were compared using a paired t-test to determine the significance of any change in QOL after surgery. The effect of other variables on change in QOL after surgery was assessed using the t-test or analysis of variance. Multifactor analysis of variance was used to assess the effect of several independent variables. RESULTS: Eighty-two patients (41 women) of 142 patients who had had surgery (58%) had complete preoperative and 30-day postoperative scores. The incidence of complications was 23% (11% were major). There was a significant improvement in QOL 30 days after surgery as measured by CGQL (0.6 ± 0.2 preoperative to 0.7 ± 0.2 postoperative; mean ± SD; p <0.001). The mean preoperative CGQL was 0.56 ± 0.24 and the mean improvement was 0.11 ± 0.20 toward a better QOL. Female patients (p <0.05) and those who did not develop complications within 30 days of surgery (p <0.05) had a significantly greater improvement in CGQL after surgery than other groups. No other factor was predictive of improved outcomes. CONCLUSIONS: QOL as measured by CGQL improves early after surgery (30 days postoperatively). Improvement in CGQL is greater in female patients and patients who do not develop complications in the postoperative period. It is not affected by other patient characteristics, nature of disease, indication, or procedure performed. Most patients who undergo surgery for Crohn's disease feel that surgery has helped them and would undergo surgery again.

Original languageEnglish (US)
Pages (from-to)714-721
Number of pages8
JournalJournal of the American College of Surgeons
Volume196
Issue number5
DOIs
StatePublished - May 1 2003
Externally publishedYes

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Ambulatory Surgical Procedures
Crohn Disease
Quality of Life
Postoperative Period
Analysis of Variance

ASJC Scopus subject areas

  • Surgery

Cite this

Delaney, C. P., Kiran, R. P., Senagore, A. J., O'Brien-Ermlich, B., Church, J., Hull, T. L., ... Fazio, V. W. (2003). Quality of life improves within 30 days of surgery for Crohn's disease. Journal of the American College of Surgeons, 196(5), 714-721. https://doi.org/10.1016/S1072-7515(03)00131-5

Quality of life improves within 30 days of surgery for Crohn's disease. / Delaney, Conor P.; Kiran, Ravi P.; Senagore, Anthony J.; O'Brien-Ermlich, Bridget; Church, James; Hull, Tracy L.; Remzi, Feza H.; Fazio, Victor W.

In: Journal of the American College of Surgeons, Vol. 196, No. 5, 01.05.2003, p. 714-721.

Research output: Contribution to journalArticle

Delaney, CP, Kiran, RP, Senagore, AJ, O'Brien-Ermlich, B, Church, J, Hull, TL, Remzi, FH & Fazio, VW 2003, 'Quality of life improves within 30 days of surgery for Crohn's disease', Journal of the American College of Surgeons, vol. 196, no. 5, pp. 714-721. https://doi.org/10.1016/S1072-7515(03)00131-5
Delaney CP, Kiran RP, Senagore AJ, O'Brien-Ermlich B, Church J, Hull TL et al. Quality of life improves within 30 days of surgery for Crohn's disease. Journal of the American College of Surgeons. 2003 May 1;196(5):714-721. https://doi.org/10.1016/S1072-7515(03)00131-5
Delaney, Conor P. ; Kiran, Ravi P. ; Senagore, Anthony J. ; O'Brien-Ermlich, Bridget ; Church, James ; Hull, Tracy L. ; Remzi, Feza H. ; Fazio, Victor W. / Quality of life improves within 30 days of surgery for Crohn's disease. In: Journal of the American College of Surgeons. 2003 ; Vol. 196, No. 5. pp. 714-721.
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abstract = "BACKGROUND: The effect of surgery on quality of life (QOL) in the early postoperative period is important in Crohn's disease because of the multiple surgical procedures that patients undergo and the acute QOL benefits that might occur as a result of modifications of medical treatment. Earlier studies of the effect of surgery on QOL have been retrospective and assessed changes 3 to 24 months after surgery. This study prospectively assesses the effect of surgery on QOL in the early postoperative period. STUDY DESIGN: Patients requiring surgical management of sequelae of Crohn's disease were obtained from a prospectively entered database including data on QOL. Preoperative and 30-day postoperative QOL were determined in 82 patients using Cleveland Global Quality of Life (CGQL) scores (range from 0 [worst] to 10 [best possible] QOL). Preoperative and postoperative scores were compared using a paired t-test to determine the significance of any change in QOL after surgery. The effect of other variables on change in QOL after surgery was assessed using the t-test or analysis of variance. Multifactor analysis of variance was used to assess the effect of several independent variables. RESULTS: Eighty-two patients (41 women) of 142 patients who had had surgery (58{\%}) had complete preoperative and 30-day postoperative scores. The incidence of complications was 23{\%} (11{\%} were major). There was a significant improvement in QOL 30 days after surgery as measured by CGQL (0.6 ± 0.2 preoperative to 0.7 ± 0.2 postoperative; mean ± SD; p <0.001). The mean preoperative CGQL was 0.56 ± 0.24 and the mean improvement was 0.11 ± 0.20 toward a better QOL. Female patients (p <0.05) and those who did not develop complications within 30 days of surgery (p <0.05) had a significantly greater improvement in CGQL after surgery than other groups. No other factor was predictive of improved outcomes. CONCLUSIONS: QOL as measured by CGQL improves early after surgery (30 days postoperatively). Improvement in CGQL is greater in female patients and patients who do not develop complications in the postoperative period. It is not affected by other patient characteristics, nature of disease, indication, or procedure performed. Most patients who undergo surgery for Crohn's disease feel that surgery has helped them and would undergo surgery again.",
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AU - Delaney, Conor P.

AU - Kiran, Ravi P.

AU - Senagore, Anthony J.

AU - O'Brien-Ermlich, Bridget

AU - Church, James

AU - Hull, Tracy L.

AU - Remzi, Feza H.

AU - Fazio, Victor W.

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N2 - BACKGROUND: The effect of surgery on quality of life (QOL) in the early postoperative period is important in Crohn's disease because of the multiple surgical procedures that patients undergo and the acute QOL benefits that might occur as a result of modifications of medical treatment. Earlier studies of the effect of surgery on QOL have been retrospective and assessed changes 3 to 24 months after surgery. This study prospectively assesses the effect of surgery on QOL in the early postoperative period. STUDY DESIGN: Patients requiring surgical management of sequelae of Crohn's disease were obtained from a prospectively entered database including data on QOL. Preoperative and 30-day postoperative QOL were determined in 82 patients using Cleveland Global Quality of Life (CGQL) scores (range from 0 [worst] to 10 [best possible] QOL). Preoperative and postoperative scores were compared using a paired t-test to determine the significance of any change in QOL after surgery. The effect of other variables on change in QOL after surgery was assessed using the t-test or analysis of variance. Multifactor analysis of variance was used to assess the effect of several independent variables. RESULTS: Eighty-two patients (41 women) of 142 patients who had had surgery (58%) had complete preoperative and 30-day postoperative scores. The incidence of complications was 23% (11% were major). There was a significant improvement in QOL 30 days after surgery as measured by CGQL (0.6 ± 0.2 preoperative to 0.7 ± 0.2 postoperative; mean ± SD; p <0.001). The mean preoperative CGQL was 0.56 ± 0.24 and the mean improvement was 0.11 ± 0.20 toward a better QOL. Female patients (p <0.05) and those who did not develop complications within 30 days of surgery (p <0.05) had a significantly greater improvement in CGQL after surgery than other groups. No other factor was predictive of improved outcomes. CONCLUSIONS: QOL as measured by CGQL improves early after surgery (30 days postoperatively). Improvement in CGQL is greater in female patients and patients who do not develop complications in the postoperative period. It is not affected by other patient characteristics, nature of disease, indication, or procedure performed. Most patients who undergo surgery for Crohn's disease feel that surgery has helped them and would undergo surgery again.

AB - BACKGROUND: The effect of surgery on quality of life (QOL) in the early postoperative period is important in Crohn's disease because of the multiple surgical procedures that patients undergo and the acute QOL benefits that might occur as a result of modifications of medical treatment. Earlier studies of the effect of surgery on QOL have been retrospective and assessed changes 3 to 24 months after surgery. This study prospectively assesses the effect of surgery on QOL in the early postoperative period. STUDY DESIGN: Patients requiring surgical management of sequelae of Crohn's disease were obtained from a prospectively entered database including data on QOL. Preoperative and 30-day postoperative QOL were determined in 82 patients using Cleveland Global Quality of Life (CGQL) scores (range from 0 [worst] to 10 [best possible] QOL). Preoperative and postoperative scores were compared using a paired t-test to determine the significance of any change in QOL after surgery. The effect of other variables on change in QOL after surgery was assessed using the t-test or analysis of variance. Multifactor analysis of variance was used to assess the effect of several independent variables. RESULTS: Eighty-two patients (41 women) of 142 patients who had had surgery (58%) had complete preoperative and 30-day postoperative scores. The incidence of complications was 23% (11% were major). There was a significant improvement in QOL 30 days after surgery as measured by CGQL (0.6 ± 0.2 preoperative to 0.7 ± 0.2 postoperative; mean ± SD; p <0.001). The mean preoperative CGQL was 0.56 ± 0.24 and the mean improvement was 0.11 ± 0.20 toward a better QOL. Female patients (p <0.05) and those who did not develop complications within 30 days of surgery (p <0.05) had a significantly greater improvement in CGQL after surgery than other groups. No other factor was predictive of improved outcomes. CONCLUSIONS: QOL as measured by CGQL improves early after surgery (30 days postoperatively). Improvement in CGQL is greater in female patients and patients who do not develop complications in the postoperative period. It is not affected by other patient characteristics, nature of disease, indication, or procedure performed. Most patients who undergo surgery for Crohn's disease feel that surgery has helped them and would undergo surgery again.

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