Quantitative immunoassay of adenosine deaminase in combined immunodeficiency disease

D. A. Carson, R. Goldblum, J. E. Seegmiller

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The authors have developed a quantitative immunoassay for the measurement of human adenosine deaminase that requires neither purified enzyme nor monospecific antibody. With this technique, cultured fibroblasts from three immunodeficient patients were shown to contain adenosine deaminase as detected both catalytically and immunochemically. In one patient the level of immunoreactive enzyme exceeded the amount of catalytically active adenosine deaminase, suggesting a structural alteration in the enzyme molecule.

Original languageEnglish (US)
Pages (from-to)270-273
Number of pages4
JournalJournal of Immunology
Issue number1
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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