Quantitative infrared spectroscopy of common bile duct gallstones

Peter F. Malet, Marta A. Dabezies, Guanghua Huang, William B. Long, Thomas R. Gadacz, Roger D. Soloway

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The aim of this study was to determine the composition of gallstones from the common bile duct of patients from the United States and the relationship of stone type to the time interval after cholecystectomy. We analyzed 56 sets of common bile duct gallstones collected over a 10-yr period using infrared and atomic absorption spectroscopy and chemical methods. Twenty-four sets (43%) of stones were cholesterol stones containing 85.3% cholesterol, 3.2% pigment, 0.6% phosphate, and 1.3% total calcium. Ten sets (18%) were black pigment stones containing 36.5% pigment, 11.4% cholesterol, 7.6% carbonate, 3.0% phosphate, and 6.2% total calcium. Twenty-two sets (39%) were brown pigment stones containing 52.7% pigment, 16.5% calcium palmitate, 10.1% cholesterol, 0.4% phosphate, and 3.4% total calcium. Most of the 26 stones found at the same time as or within several months after cholecystectomy were either cholesterol (69%) or black pigment (19%). In contrast, the majority (59%) of the 22 common duct stones that were diagnosed ≥21 mo after cholecystectomy were brown pigment stones. In conclusion, brown pigment stones are a distinct type of pigment stone characterized by their content of substantial amounts of calcium palmitate. They comprise a significant proportion of common duct stones in this series of United States patients, particularly of those found ≥21 mo after cholecystectomy.

Original languageEnglish (US)
Pages (from-to)1217-1221
Number of pages5
JournalGastroenterology
Volume94
Issue number5 PART 1
StatePublished - 1988
Externally publishedYes

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Cholecystectomy
Gallstones
Spectrum Analysis
Cholesterol
Palmitic Acid
Calcium
Phosphates
Carbonates

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Malet, P. F., Dabezies, M. A., Huang, G., Long, W. B., Gadacz, T. R., & Soloway, R. D. (1988). Quantitative infrared spectroscopy of common bile duct gallstones. Gastroenterology, 94(5 PART 1), 1217-1221.

Quantitative infrared spectroscopy of common bile duct gallstones. / Malet, Peter F.; Dabezies, Marta A.; Huang, Guanghua; Long, William B.; Gadacz, Thomas R.; Soloway, Roger D.

In: Gastroenterology, Vol. 94, No. 5 PART 1, 1988, p. 1217-1221.

Research output: Contribution to journalArticle

Malet, PF, Dabezies, MA, Huang, G, Long, WB, Gadacz, TR & Soloway, RD 1988, 'Quantitative infrared spectroscopy of common bile duct gallstones', Gastroenterology, vol. 94, no. 5 PART 1, pp. 1217-1221.
Malet PF, Dabezies MA, Huang G, Long WB, Gadacz TR, Soloway RD. Quantitative infrared spectroscopy of common bile duct gallstones. Gastroenterology. 1988;94(5 PART 1):1217-1221.
Malet, Peter F. ; Dabezies, Marta A. ; Huang, Guanghua ; Long, William B. ; Gadacz, Thomas R. ; Soloway, Roger D. / Quantitative infrared spectroscopy of common bile duct gallstones. In: Gastroenterology. 1988 ; Vol. 94, No. 5 PART 1. pp. 1217-1221.
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