@inproceedings{d521c994d09d4fe587d52b9092bb9a9f,
title = "Quantitative spectrally resolved intraoperative fluorescence imaging for neurosurgical guidance in brain tumor surgery: Pre-clinical and clinical results",
abstract = "Fluorescence-guidance is a useful adjunct to maximize brain tumor resection but current commercial systems are limited by subjective assessment of fluorescence, low sensitivity and non-spectrally-resolved detection. We present a quantitative, spectrally-resolved system integrated onto a commercial neurosurgical microscope that performs spectrallyresolved detection and corrects for effects of tissue optical absorption and scattering on the detected fluorescence signal to image the true fluorophore concentration. Pre-clinical studies in rodent glioma models using multiple fluorophores (PpIX, fluorescein) and clinical studies demonstrate improved residual tumor tissue detection. This quantitative, spectrally-resolved technique opens the door to simultaneous image-guided surgery of multiple fluorophores in the visible and near infrared.",
author = "Vald{\'e}s, {Pablo A.} and Jacobs, {Valerie L.} and Frederic Leblond and Wilson, {Brian C.} and Paulsen, {Keith D.} and Roberts, {David W.}",
year = "2014",
doi = "10.1117/12.2039090",
language = "English (US)",
isbn = "9780819498410",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics",
note = "Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics ; Conference date: 01-02-2014 Through 04-02-2014",
}