Quantitative spectrally resolved intraoperative fluorescence imaging for neurosurgical guidance in brain tumor surgery: Pre-clinical and clinical results

Pablo A. Valdés, Valerie L. Jacobs, Frederic Leblond, Brian C. Wilson, Keith D. Paulsen, David W. Roberts

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Fluorescence-guidance is a useful adjunct to maximize brain tumor resection but current commercial systems are limited by subjective assessment of fluorescence, low sensitivity and non-spectrally-resolved detection. We present a quantitative, spectrally-resolved system integrated onto a commercial neurosurgical microscope that performs spectrallyresolved detection and corrects for effects of tissue optical absorption and scattering on the detected fluorescence signal to image the true fluorophore concentration. Pre-clinical studies in rodent glioma models using multiple fluorophores (PpIX, fluorescein) and clinical studies demonstrate improved residual tumor tissue detection. This quantitative, spectrally-resolved technique opens the door to simultaneous image-guided surgery of multiple fluorophores in the visible and near infrared.

Original languageEnglish (US)
Title of host publicationOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics
PublisherSPIE
ISBN (Print)9780819498410
DOIs
StatePublished - 2014
Externally publishedYes
EventOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics - San Francisco, CA, United States
Duration: Feb 1 2014Feb 4 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8928
ISSN (Print)1605-7422

Conference

ConferenceOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics
Country/TerritoryUnited States
CitySan Francisco, CA
Period2/1/142/4/14

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials

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