R type virus like particles in avian sarcoma virus induced rat central nervous system tumors

M. W. Cloyd, P. C. Burger, D. D. Bigner

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Morphologically distinct virus like particles (VLP), similar to R type VLP, were observed by electron microscopy in experimental rat central nervous system tumors induced with the B-77-C strain of avian sarcoma virus (ASV). R-type VLP have a characteristic internal radial structure and were observed previously only in hamster cells and in an established bovine cell line. They were not observed in the B-77 ASV inoculum used to induce the rat tumors or in the B-77 induced hamster glioma cells from which the B-77 was rescued. Nevertheless, the genome of an endogenous hamster R-type particle also might have been rescued and carried in the B-77 inoculum. Alternatively, R-type VLP may exist in a number of animal species, including the rat, and may be expressed in certain conditions such as neoplastic transformation.

Original languageEnglish (US)
Pages (from-to)1479-1481
Number of pages3
JournalJournal of the National Cancer Institute
Volume54
Issue number6
StatePublished - 1975

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Avian Sarcoma Viruses
Central Nervous System Neoplasms
Virion
Cricetinae
Glioma
Electron Microscopy
Genome
Cell Line
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

R type virus like particles in avian sarcoma virus induced rat central nervous system tumors. / Cloyd, M. W.; Burger, P. C.; Bigner, D. D.

In: Journal of the National Cancer Institute, Vol. 54, No. 6, 1975, p. 1479-1481.

Research output: Contribution to journalArticle

Cloyd, M. W. ; Burger, P. C. ; Bigner, D. D. / R type virus like particles in avian sarcoma virus induced rat central nervous system tumors. In: Journal of the National Cancer Institute. 1975 ; Vol. 54, No. 6. pp. 1479-1481.
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