TY - JOUR
T1 - R type virus like particles in avian sarcoma virus induced rat central nervous system tumors
AU - Cloyd, M. W.
AU - Burger, P. C.
AU - Bigner, D. D.
PY - 1975
Y1 - 1975
N2 - Morphologically distinct virus like particles (VLP), similar to R type VLP, were observed by electron microscopy in experimental rat central nervous system tumors induced with the B-77-C strain of avian sarcoma virus (ASV). R-type VLP have a characteristic internal radial structure and were observed previously only in hamster cells and in an established bovine cell line. They were not observed in the B-77 ASV inoculum used to induce the rat tumors or in the B-77 induced hamster glioma cells from which the B-77 was rescued. Nevertheless, the genome of an endogenous hamster R-type particle also might have been rescued and carried in the B-77 inoculum. Alternatively, R-type VLP may exist in a number of animal species, including the rat, and may be expressed in certain conditions such as neoplastic transformation.
AB - Morphologically distinct virus like particles (VLP), similar to R type VLP, were observed by electron microscopy in experimental rat central nervous system tumors induced with the B-77-C strain of avian sarcoma virus (ASV). R-type VLP have a characteristic internal radial structure and were observed previously only in hamster cells and in an established bovine cell line. They were not observed in the B-77 ASV inoculum used to induce the rat tumors or in the B-77 induced hamster glioma cells from which the B-77 was rescued. Nevertheless, the genome of an endogenous hamster R-type particle also might have been rescued and carried in the B-77 inoculum. Alternatively, R-type VLP may exist in a number of animal species, including the rat, and may be expressed in certain conditions such as neoplastic transformation.
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U2 - 10.1093/jnci/54.6.1479
DO - 10.1093/jnci/54.6.1479
M3 - Article
C2 - 166194
AN - SCOPUS:0016833741
SN - 0027-8874
VL - 54
SP - 1479
EP - 1481
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 6
ER -