R type virus like particles in avian sarcoma virus induced rat central nervous system tumors

M. W. Cloyd, P. C. Burger, D. D. Bigner

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Morphologically distinct virus like particles (VLP), similar to R type VLP, were observed by electron microscopy in experimental rat central nervous system tumors induced with the B-77-C strain of avian sarcoma virus (ASV). R-type VLP have a characteristic internal radial structure and were observed previously only in hamster cells and in an established bovine cell line. They were not observed in the B-77 ASV inoculum used to induce the rat tumors or in the B-77 induced hamster glioma cells from which the B-77 was rescued. Nevertheless, the genome of an endogenous hamster R-type particle also might have been rescued and carried in the B-77 inoculum. Alternatively, R-type VLP may exist in a number of animal species, including the rat, and may be expressed in certain conditions such as neoplastic transformation.

Original languageEnglish (US)
Pages (from-to)1479-1481
Number of pages3
JournalJournal of the National Cancer Institute
Volume54
Issue number6
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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