Racial and Ethnic Disparities in Nasopharyngeal Cancer Survival in the United States

Vishal J. Patel, Nai Wei Chen, Vicente Resto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective To determine whether patient race and ethnicity affect nasopharyngeal cancer survival. Study Design Retrospective database analysis. Setting National Cancer Institute's SEER database (Surveillance, Epidemiology, and End Results), 1988-2010. Subjects and Methods Nasopharyngeal carcinoma cases were extracted according to site codes and histology recode-broad groupings. The cohort of 5427 patients was used to calculate disease-specific survival in regard to race and ethnicity. Extracted data were further analyzed through direct comparisons and multivariable Cox regression models controlling for patient, tumor, and treatment characteristics. Results Unadjusted survival curves for all nasopharyngeal carcinomas considered together showed a statistically significant better disease-specific survival for the African American race (P =.02) and Asian ethnicity (P =.01) relative to Caucasian patients. The survival advantage for both these groups was eliminated after controlling for the age and sex of the patients. Conclusion African American and Asian patients with nasopharyngeal cancer have better disease-specific survival as compared with Caucasian patients, while Hispanic ethnicity has no effect relative to Caucasians. This disparity is accounted for by diagnosis at an older age in Caucasian patients but remains poorly explained in regard to Hispanic patients.

Original languageEnglish (US)
Pages (from-to)122-131
Number of pages10
JournalOtolaryngology - Head and Neck Surgery (United States)
Volume156
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Nasopharyngeal Neoplasms
Survival
Hispanic Americans
African Americans
Databases
National Cancer Institute (U.S.)
Proportional Hazards Models
Histology
Epidemiology
Retrospective Studies

Keywords

  • cancer
  • disparity
  • ethnicity
  • nasopharyngeal
  • race
  • survival

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Racial and Ethnic Disparities in Nasopharyngeal Cancer Survival in the United States. / Patel, Vishal J.; Chen, Nai Wei; Resto, Vicente.

In: Otolaryngology - Head and Neck Surgery (United States), Vol. 156, No. 1, 01.01.2017, p. 122-131.

Research output: Contribution to journalArticle

@article{d60f8a2d7a0c454f915880c4a783182c,
title = "Racial and Ethnic Disparities in Nasopharyngeal Cancer Survival in the United States",
abstract = "Objective To determine whether patient race and ethnicity affect nasopharyngeal cancer survival. Study Design Retrospective database analysis. Setting National Cancer Institute's SEER database (Surveillance, Epidemiology, and End Results), 1988-2010. Subjects and Methods Nasopharyngeal carcinoma cases were extracted according to site codes and histology recode-broad groupings. The cohort of 5427 patients was used to calculate disease-specific survival in regard to race and ethnicity. Extracted data were further analyzed through direct comparisons and multivariable Cox regression models controlling for patient, tumor, and treatment characteristics. Results Unadjusted survival curves for all nasopharyngeal carcinomas considered together showed a statistically significant better disease-specific survival for the African American race (P =.02) and Asian ethnicity (P =.01) relative to Caucasian patients. The survival advantage for both these groups was eliminated after controlling for the age and sex of the patients. Conclusion African American and Asian patients with nasopharyngeal cancer have better disease-specific survival as compared with Caucasian patients, while Hispanic ethnicity has no effect relative to Caucasians. This disparity is accounted for by diagnosis at an older age in Caucasian patients but remains poorly explained in regard to Hispanic patients.",
keywords = "cancer, disparity, ethnicity, nasopharyngeal, race, survival",
author = "Patel, {Vishal J.} and Chen, {Nai Wei} and Vicente Resto",
year = "2017",
month = "1",
day = "1",
doi = "10.1177/0194599816672625",
language = "English (US)",
volume = "156",
pages = "122--131",
journal = "Otolaryngology - Head and Neck Surgery (United States)",
issn = "0194-5998",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Racial and Ethnic Disparities in Nasopharyngeal Cancer Survival in the United States

AU - Patel, Vishal J.

AU - Chen, Nai Wei

AU - Resto, Vicente

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective To determine whether patient race and ethnicity affect nasopharyngeal cancer survival. Study Design Retrospective database analysis. Setting National Cancer Institute's SEER database (Surveillance, Epidemiology, and End Results), 1988-2010. Subjects and Methods Nasopharyngeal carcinoma cases were extracted according to site codes and histology recode-broad groupings. The cohort of 5427 patients was used to calculate disease-specific survival in regard to race and ethnicity. Extracted data were further analyzed through direct comparisons and multivariable Cox regression models controlling for patient, tumor, and treatment characteristics. Results Unadjusted survival curves for all nasopharyngeal carcinomas considered together showed a statistically significant better disease-specific survival for the African American race (P =.02) and Asian ethnicity (P =.01) relative to Caucasian patients. The survival advantage for both these groups was eliminated after controlling for the age and sex of the patients. Conclusion African American and Asian patients with nasopharyngeal cancer have better disease-specific survival as compared with Caucasian patients, while Hispanic ethnicity has no effect relative to Caucasians. This disparity is accounted for by diagnosis at an older age in Caucasian patients but remains poorly explained in regard to Hispanic patients.

AB - Objective To determine whether patient race and ethnicity affect nasopharyngeal cancer survival. Study Design Retrospective database analysis. Setting National Cancer Institute's SEER database (Surveillance, Epidemiology, and End Results), 1988-2010. Subjects and Methods Nasopharyngeal carcinoma cases were extracted according to site codes and histology recode-broad groupings. The cohort of 5427 patients was used to calculate disease-specific survival in regard to race and ethnicity. Extracted data were further analyzed through direct comparisons and multivariable Cox regression models controlling for patient, tumor, and treatment characteristics. Results Unadjusted survival curves for all nasopharyngeal carcinomas considered together showed a statistically significant better disease-specific survival for the African American race (P =.02) and Asian ethnicity (P =.01) relative to Caucasian patients. The survival advantage for both these groups was eliminated after controlling for the age and sex of the patients. Conclusion African American and Asian patients with nasopharyngeal cancer have better disease-specific survival as compared with Caucasian patients, while Hispanic ethnicity has no effect relative to Caucasians. This disparity is accounted for by diagnosis at an older age in Caucasian patients but remains poorly explained in regard to Hispanic patients.

KW - cancer

KW - disparity

KW - ethnicity

KW - nasopharyngeal

KW - race

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=85008474583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85008474583&partnerID=8YFLogxK

U2 - 10.1177/0194599816672625

DO - 10.1177/0194599816672625

M3 - Article

VL - 156

SP - 122

EP - 131

JO - Otolaryngology - Head and Neck Surgery (United States)

JF - Otolaryngology - Head and Neck Surgery (United States)

SN - 0194-5998

IS - 1

ER -