Racial disparity in amniotic fluid concentrations of tumor necrosis factor (TNF)-α and soluble TNF receptors in spontaneous preterm birth

Ramkumar Menon, Poul Thorsen, Ida Vogel, Bo Jacobsson, Nicole Morgan, Lan Jiang, Chun Li, Scott M. Williams, Stephen J. Fortunato

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Objective: Preterm birth rate in the United States is higher in blacks than whites. It has been hypothesized that a differential inflammatory response may explain this disparity. The objective of this study is to examine the inflammatory cytokine, tumor necrosis factor (TNF)-α and soluble TNF receptor concentrations (sTNFR1 and sTNFR2) in the amniotic fluid of black and white women at delivery. Study Design: Amniotic fluid samples were collected during active labor from 158 cases (preterm births, gestational age 220/7 weeks to 360/7 weeks, 52 black and 106 white) and 175 controls (term births, gestational age 370/7 weeks to 420/7 weeks, 87 black and 88 white) at Centennial Women's Hospital, Nashville, TN. Amniotic fluid TNF-α, sTNFR1, and sTNFR2 concentrations and the molar ratios of TNF-α to its receptors were compared between cases and controls within each racial group. Results: Median TNF-α concentration was associated with preterm birth when whites and blacks were analyzed together, with cases having higher values (191.5 pg/mL) than controls (68.9 pg/mL; P < .001). There were no significant associations with sTNFR1 or sTNFR2 concentrations between cases (2409.4 and 2934.3 pg/mL, respectively) and controls (2759.9 and 3084.1 pg/mL, respectively) when the racial groups were analyzed together (P = .08, P = .4, respectively). Black cases associated with higher TNF-α concentrations (1287.0 pg/mL in cases and 67.3 pg/mL in controls; P < .001). In whites there was no association between TNF-α and preterm birth (P = .3). The molar ratio of TNF-α/total sTNFR (R1 plus R2) associated with higher TNF-α in black cases, compared with black controls (P < .001). There was no significant association between white cases and controls for ligand receptor ratios (P = .3). Conclusion: The TNF-α/sTNFR profile in pregnancy differs between racial groups, suggesting a difference in bioavailability of TNF-α. The larger molar ratio of TNF-α/sTNFR in black cases may be indicative of a TNF-α mediated pathological process of preterm birth in blacks but not in whites.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume198
Issue number5
DOIs
StatePublished - May 2008
Externally publishedYes

Fingerprint

Tumor Necrosis Factor Receptors
Premature Birth
Amniotic Fluid
Tumor Necrosis Factor-alpha
Gestational Age
Term Birth
Birth Rate
Pathologic Processes
Biological Availability
hydroquinone
Cytokines

Keywords

  • cytokines
  • ethnicity
  • inflammation
  • prematurity
  • preterm labor

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Racial disparity in amniotic fluid concentrations of tumor necrosis factor (TNF)-α and soluble TNF receptors in spontaneous preterm birth. / Menon, Ramkumar; Thorsen, Poul; Vogel, Ida; Jacobsson, Bo; Morgan, Nicole; Jiang, Lan; Li, Chun; Williams, Scott M.; Fortunato, Stephen J.

In: American Journal of Obstetrics and Gynecology, Vol. 198, No. 5, 05.2008.

Research output: Contribution to journalArticle

Menon, Ramkumar ; Thorsen, Poul ; Vogel, Ida ; Jacobsson, Bo ; Morgan, Nicole ; Jiang, Lan ; Li, Chun ; Williams, Scott M. ; Fortunato, Stephen J. / Racial disparity in amniotic fluid concentrations of tumor necrosis factor (TNF)-α and soluble TNF receptors in spontaneous preterm birth. In: American Journal of Obstetrics and Gynecology. 2008 ; Vol. 198, No. 5.
@article{1663bd60dfce4d5d8a75f38140ca2247,
title = "Racial disparity in amniotic fluid concentrations of tumor necrosis factor (TNF)-α and soluble TNF receptors in spontaneous preterm birth",
abstract = "Objective: Preterm birth rate in the United States is higher in blacks than whites. It has been hypothesized that a differential inflammatory response may explain this disparity. The objective of this study is to examine the inflammatory cytokine, tumor necrosis factor (TNF)-α and soluble TNF receptor concentrations (sTNFR1 and sTNFR2) in the amniotic fluid of black and white women at delivery. Study Design: Amniotic fluid samples were collected during active labor from 158 cases (preterm births, gestational age 220/7 weeks to 360/7 weeks, 52 black and 106 white) and 175 controls (term births, gestational age 370/7 weeks to 420/7 weeks, 87 black and 88 white) at Centennial Women's Hospital, Nashville, TN. Amniotic fluid TNF-α, sTNFR1, and sTNFR2 concentrations and the molar ratios of TNF-α to its receptors were compared between cases and controls within each racial group. Results: Median TNF-α concentration was associated with preterm birth when whites and blacks were analyzed together, with cases having higher values (191.5 pg/mL) than controls (68.9 pg/mL; P < .001). There were no significant associations with sTNFR1 or sTNFR2 concentrations between cases (2409.4 and 2934.3 pg/mL, respectively) and controls (2759.9 and 3084.1 pg/mL, respectively) when the racial groups were analyzed together (P = .08, P = .4, respectively). Black cases associated with higher TNF-α concentrations (1287.0 pg/mL in cases and 67.3 pg/mL in controls; P < .001). In whites there was no association between TNF-α and preterm birth (P = .3). The molar ratio of TNF-α/total sTNFR (R1 plus R2) associated with higher TNF-α in black cases, compared with black controls (P < .001). There was no significant association between white cases and controls for ligand receptor ratios (P = .3). Conclusion: The TNF-α/sTNFR profile in pregnancy differs between racial groups, suggesting a difference in bioavailability of TNF-α. The larger molar ratio of TNF-α/sTNFR in black cases may be indicative of a TNF-α mediated pathological process of preterm birth in blacks but not in whites.",
keywords = "cytokines, ethnicity, inflammation, prematurity, preterm labor",
author = "Ramkumar Menon and Poul Thorsen and Ida Vogel and Bo Jacobsson and Nicole Morgan and Lan Jiang and Chun Li and Williams, {Scott M.} and Fortunato, {Stephen J.}",
year = "2008",
month = "5",
doi = "10.1016/j.ajog.2007.11.025",
language = "English (US)",
volume = "198",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Racial disparity in amniotic fluid concentrations of tumor necrosis factor (TNF)-α and soluble TNF receptors in spontaneous preterm birth

AU - Menon, Ramkumar

AU - Thorsen, Poul

AU - Vogel, Ida

AU - Jacobsson, Bo

AU - Morgan, Nicole

AU - Jiang, Lan

AU - Li, Chun

AU - Williams, Scott M.

AU - Fortunato, Stephen J.

PY - 2008/5

Y1 - 2008/5

N2 - Objective: Preterm birth rate in the United States is higher in blacks than whites. It has been hypothesized that a differential inflammatory response may explain this disparity. The objective of this study is to examine the inflammatory cytokine, tumor necrosis factor (TNF)-α and soluble TNF receptor concentrations (sTNFR1 and sTNFR2) in the amniotic fluid of black and white women at delivery. Study Design: Amniotic fluid samples were collected during active labor from 158 cases (preterm births, gestational age 220/7 weeks to 360/7 weeks, 52 black and 106 white) and 175 controls (term births, gestational age 370/7 weeks to 420/7 weeks, 87 black and 88 white) at Centennial Women's Hospital, Nashville, TN. Amniotic fluid TNF-α, sTNFR1, and sTNFR2 concentrations and the molar ratios of TNF-α to its receptors were compared between cases and controls within each racial group. Results: Median TNF-α concentration was associated with preterm birth when whites and blacks were analyzed together, with cases having higher values (191.5 pg/mL) than controls (68.9 pg/mL; P < .001). There were no significant associations with sTNFR1 or sTNFR2 concentrations between cases (2409.4 and 2934.3 pg/mL, respectively) and controls (2759.9 and 3084.1 pg/mL, respectively) when the racial groups were analyzed together (P = .08, P = .4, respectively). Black cases associated with higher TNF-α concentrations (1287.0 pg/mL in cases and 67.3 pg/mL in controls; P < .001). In whites there was no association between TNF-α and preterm birth (P = .3). The molar ratio of TNF-α/total sTNFR (R1 plus R2) associated with higher TNF-α in black cases, compared with black controls (P < .001). There was no significant association between white cases and controls for ligand receptor ratios (P = .3). Conclusion: The TNF-α/sTNFR profile in pregnancy differs between racial groups, suggesting a difference in bioavailability of TNF-α. The larger molar ratio of TNF-α/sTNFR in black cases may be indicative of a TNF-α mediated pathological process of preterm birth in blacks but not in whites.

AB - Objective: Preterm birth rate in the United States is higher in blacks than whites. It has been hypothesized that a differential inflammatory response may explain this disparity. The objective of this study is to examine the inflammatory cytokine, tumor necrosis factor (TNF)-α and soluble TNF receptor concentrations (sTNFR1 and sTNFR2) in the amniotic fluid of black and white women at delivery. Study Design: Amniotic fluid samples were collected during active labor from 158 cases (preterm births, gestational age 220/7 weeks to 360/7 weeks, 52 black and 106 white) and 175 controls (term births, gestational age 370/7 weeks to 420/7 weeks, 87 black and 88 white) at Centennial Women's Hospital, Nashville, TN. Amniotic fluid TNF-α, sTNFR1, and sTNFR2 concentrations and the molar ratios of TNF-α to its receptors were compared between cases and controls within each racial group. Results: Median TNF-α concentration was associated with preterm birth when whites and blacks were analyzed together, with cases having higher values (191.5 pg/mL) than controls (68.9 pg/mL; P < .001). There were no significant associations with sTNFR1 or sTNFR2 concentrations between cases (2409.4 and 2934.3 pg/mL, respectively) and controls (2759.9 and 3084.1 pg/mL, respectively) when the racial groups were analyzed together (P = .08, P = .4, respectively). Black cases associated with higher TNF-α concentrations (1287.0 pg/mL in cases and 67.3 pg/mL in controls; P < .001). In whites there was no association between TNF-α and preterm birth (P = .3). The molar ratio of TNF-α/total sTNFR (R1 plus R2) associated with higher TNF-α in black cases, compared with black controls (P < .001). There was no significant association between white cases and controls for ligand receptor ratios (P = .3). Conclusion: The TNF-α/sTNFR profile in pregnancy differs between racial groups, suggesting a difference in bioavailability of TNF-α. The larger molar ratio of TNF-α/sTNFR in black cases may be indicative of a TNF-α mediated pathological process of preterm birth in blacks but not in whites.

KW - cytokines

KW - ethnicity

KW - inflammation

KW - prematurity

KW - preterm labor

UR - http://www.scopus.com/inward/record.url?scp=42749096696&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42749096696&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2007.11.025

DO - 10.1016/j.ajog.2007.11.025

M3 - Article

VL - 198

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 5

ER -