Radiation carcinogenesis: Time-dose relationships

R. L. Ullrich, M. C. Jernigan, L. C. Satterfield, N. D. Bowles

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The present studies were undertaken to examine the time-dose relationships for the induction of lung adenocarcinomas and mammary adenocarcinomas in female BALB/c mice following γ irradiation. Twelve-week-old female BALB/c/An NBd mice were irradiated with 137Cs γ rays, and lifetime tumor incidences following high-dose-rate, low-dose-rate, or fractionated exposure regimens were compared. Analysis of the results indicated that the data could be fitted by linear-quadratic dose-response models for the induction of both tumors following acute doses and a linear model with a slope similar to that for the linear portion of the linear quadratic following low-dose-rate exposure regimens. When doses were fractionated the response was dependent upon the dose per fraction. If the dose per fraction was a dose which was predominantly on the linear portion of the acute dose response curve, then the response was linear and similar to that after low-dose-rate exposures. If the dose per fraction was in a region where the quadratic portion of the acute dose-response was significant, then the tumor incidence was higher than that following low-dose-rate exposures.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalRadiation Research
Volume111
Issue number1
StatePublished - 1987
Externally publishedYes

Fingerprint

carcinogenesis
Carcinogenesis
Radiation
dosage
radiation
Neoplasms
Incidence
Linear Models
Adenocarcinoma
Breast
dose response
adenocarcinoma
tumors
neoplasms
mice
induction
incidence
breasts
irradiation
linear models

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Ullrich, R. L., Jernigan, M. C., Satterfield, L. C., & Bowles, N. D. (1987). Radiation carcinogenesis: Time-dose relationships. Radiation Research, 111(1), 179-184.

Radiation carcinogenesis : Time-dose relationships. / Ullrich, R. L.; Jernigan, M. C.; Satterfield, L. C.; Bowles, N. D.

In: Radiation Research, Vol. 111, No. 1, 1987, p. 179-184.

Research output: Contribution to journalArticle

Ullrich, RL, Jernigan, MC, Satterfield, LC & Bowles, ND 1987, 'Radiation carcinogenesis: Time-dose relationships', Radiation Research, vol. 111, no. 1, pp. 179-184.
Ullrich RL, Jernigan MC, Satterfield LC, Bowles ND. Radiation carcinogenesis: Time-dose relationships. Radiation Research. 1987;111(1):179-184.
Ullrich, R. L. ; Jernigan, M. C. ; Satterfield, L. C. ; Bowles, N. D. / Radiation carcinogenesis : Time-dose relationships. In: Radiation Research. 1987 ; Vol. 111, No. 1. pp. 179-184.
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