Radiation carcinogenesis: Time-dose relationships

R. L. Ullrich, M. C. Jernigan, L. C. Satterfield, N. D. Bowles

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


The present studies were undertaken to examine the time-dose relationships for the induction of lung adenocarcinomas and mammary adenocarcinomas in female BALB/c mice following γ irradiation. Twelve-week-old female BALB/c/An NBd mice were irradiated with 137Cs γ rays, and lifetime tumor incidences following high-dose-rate, low-dose-rate, or fractionated exposure regimens were compared. Analysis of the results indicated that the data could be fitted by linear-quadratic dose-response models for the induction of both tumors following acute doses and a linear model with a slope similar to that for the linear portion of the linear quadratic following low-dose-rate exposure regimens. When doses were fractionated the response was dependent upon the dose per fraction. If the dose per fraction was a dose which was predominantly on the linear portion of the acute dose response curve, then the response was linear and similar to that after low-dose-rate exposures. If the dose per fraction was in a region where the quadratic portion of the acute dose-response was significant, then the tumor incidence was higher than that following low-dose-rate exposures.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalRadiation research
Issue number1
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging


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