Abstract
Patients who are infected with the human immunodeficiency virus (HIV) may develop benign lymphoepithelial cysts within the parotid gland that cause severe facial deformity. Standard treatment for this disorder has been superficial parotidectomy, repeated fine-needle aspirations or observation alone. These approaches are unsatisfactory because elective surgery in immunocompromised patients should be avoided, the cysts recur soon after aspiration, and observation alone for a treatable deforming facial process is unacceptable. Radiotherapy's proven effectiveness in treating other benign disorders of the parotid gland led us to evaluate its usefulness as a treatment for this disorder. Eight patients with parotid enlargement, who were seropositive for HIV, received 8-10 Gy to the parotids in 1 week. Five patients had complete response and three patients had partial response. All were very satisfied with the cosmetic result. Treatment-related toxicity was well tolerated and consisted of mild xerostomia and transient taste loss. In all cases, these side effects resolved within 1 month. Radiation therapy thus appears to be an effective and well-tolerated treatment for AIDS-related parotid enlargement.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1045-1050 |
| Number of pages | 6 |
| Journal | International Journal of Radiation Oncology, Biology, Physics |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- Acquired immunodeficiency syndrome
- AIDS
- Parotid gland
- Radiation therapy
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Radiation
Cite this
Radiation therapy as a treatment for benign lymphoepithelial parotid cysts in patients infected with human immunodefiency virus-1. / Goldstein, Jeffrey; Rubin, John; Silver, Carl; Meritz, Keith; Chao, Celia; Ting, Joseph; Davis, Lawrence.
In: International Journal of Radiation Oncology, Biology, Physics, Vol. 23, No. 5, 1992, p. 1045-1050.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radiation therapy as a treatment for benign lymphoepithelial parotid cysts in patients infected with human immunodefiency virus-1
AU - Goldstein, Jeffrey
AU - Rubin, John
AU - Silver, Carl
AU - Meritz, Keith
AU - Chao, Celia
AU - Ting, Joseph
AU - Davis, Lawrence
PY - 1992
Y1 - 1992
N2 - Patients who are infected with the human immunodeficiency virus (HIV) may develop benign lymphoepithelial cysts within the parotid gland that cause severe facial deformity. Standard treatment for this disorder has been superficial parotidectomy, repeated fine-needle aspirations or observation alone. These approaches are unsatisfactory because elective surgery in immunocompromised patients should be avoided, the cysts recur soon after aspiration, and observation alone for a treatable deforming facial process is unacceptable. Radiotherapy's proven effectiveness in treating other benign disorders of the parotid gland led us to evaluate its usefulness as a treatment for this disorder. Eight patients with parotid enlargement, who were seropositive for HIV, received 8-10 Gy to the parotids in 1 week. Five patients had complete response and three patients had partial response. All were very satisfied with the cosmetic result. Treatment-related toxicity was well tolerated and consisted of mild xerostomia and transient taste loss. In all cases, these side effects resolved within 1 month. Radiation therapy thus appears to be an effective and well-tolerated treatment for AIDS-related parotid enlargement.
AB - Patients who are infected with the human immunodeficiency virus (HIV) may develop benign lymphoepithelial cysts within the parotid gland that cause severe facial deformity. Standard treatment for this disorder has been superficial parotidectomy, repeated fine-needle aspirations or observation alone. These approaches are unsatisfactory because elective surgery in immunocompromised patients should be avoided, the cysts recur soon after aspiration, and observation alone for a treatable deforming facial process is unacceptable. Radiotherapy's proven effectiveness in treating other benign disorders of the parotid gland led us to evaluate its usefulness as a treatment for this disorder. Eight patients with parotid enlargement, who were seropositive for HIV, received 8-10 Gy to the parotids in 1 week. Five patients had complete response and three patients had partial response. All were very satisfied with the cosmetic result. Treatment-related toxicity was well tolerated and consisted of mild xerostomia and transient taste loss. In all cases, these side effects resolved within 1 month. Radiation therapy thus appears to be an effective and well-tolerated treatment for AIDS-related parotid enlargement.
KW - Acquired immunodeficiency syndrome
KW - AIDS
KW - Parotid gland
KW - Radiation therapy
UR - http://www.scopus.com/inward/record.url?scp=0026650055&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026650055&partnerID=8YFLogxK
U2 - 10.1016/0360-3016(92)90912-2
DO - 10.1016/0360-3016(92)90912-2
M3 - Article
C2 - 1639639
AN - SCOPUS:0026650055
VL - 23
SP - 1045
EP - 1050
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
SN - 0360-3016
IS - 5
ER -