Radiobiological studies of human hybrid cells (skin fibroblasts × hela) and their tumourigenic segregants

J. L. Redpath; C. Sun; M. Colman; E. J. Stanbridge

doi:10.1080/09553008514551541

Radiobiological studies of human hybrid cells (skin fibroblasts × hela) and their tumourigenic segregants

J. L. Redpath, C. Sun, M. Colman, E. J. Stanbridge

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Data are presented on the survival characteristics following γirradiation of a human hybrid cell line (skin fibroblasts × HeLa), and its tumourigenic segregant, which indicate that transition from the non-tumourigenic to the tumourigenic state is associated with a decrease in the ability to accumulate and repair sublethal damage. Previous studies have demonstrated that this transition to the tumourigenic state is also associated with loss of specific chromosomes (one copy each of chromosomes 11 and 14). It is suggested that this loss of chromosomes may account for the change in radiosensitivity.

Original language	English (US)
Pages (from-to)	479-483
Number of pages	5
Journal	International Journal of Radiation Biology
Volume	48
Issue number	4
DOIs	https://doi.org/10.1080/09553008514551541
State	Published - 1985
Externally published	Yes

Keywords

Human hybrid cells
Non-tumourigenic
Sub-lethal damage repair
Tumourigenic

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1080/09553008514551541

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title = "Radiobiological studies of human hybrid cells (skin fibroblasts × hela) and their tumourigenic segregants",

abstract = "Data are presented on the survival characteristics following γirradiation of a human hybrid cell line (skin fibroblasts × HeLa), and its tumourigenic segregant, which indicate that transition from the non-tumourigenic to the tumourigenic state is associated with a decrease in the ability to accumulate and repair sublethal damage. Previous studies have demonstrated that this transition to the tumourigenic state is also associated with loss of specific chromosomes (one copy each of chromosomes 11 and 14). It is suggested that this loss of chromosomes may account for the change in radiosensitivity.",

keywords = "Human hybrid cells, Non-tumourigenic, Sub-lethal damage repair, Tumourigenic",

author = "Redpath, {J. L.} and C. Sun and M. Colman and Stanbridge, {E. J.}",

note = "Funding Information: We are grateful to the Phi Beta Psi Sorority for supporting this research. supported, in part, by NIH Grant CA 19401 (EJS).",

year = "1985",

doi = "10.1080/09553008514551541",

language = "English (US)",

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journal = "International Journal of Radiation Biology",

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TY - JOUR

T1 - Radiobiological studies of human hybrid cells (skin fibroblasts × hela) and their tumourigenic segregants

AU - Redpath, J. L.

AU - Sun, C.

AU - Colman, M.

AU - Stanbridge, E. J.

N1 - Funding Information: We are grateful to the Phi Beta Psi Sorority for supporting this research. supported, in part, by NIH Grant CA 19401 (EJS).

PY - 1985

Y1 - 1985

N2 - Data are presented on the survival characteristics following γirradiation of a human hybrid cell line (skin fibroblasts × HeLa), and its tumourigenic segregant, which indicate that transition from the non-tumourigenic to the tumourigenic state is associated with a decrease in the ability to accumulate and repair sublethal damage. Previous studies have demonstrated that this transition to the tumourigenic state is also associated with loss of specific chromosomes (one copy each of chromosomes 11 and 14). It is suggested that this loss of chromosomes may account for the change in radiosensitivity.

AB - Data are presented on the survival characteristics following γirradiation of a human hybrid cell line (skin fibroblasts × HeLa), and its tumourigenic segregant, which indicate that transition from the non-tumourigenic to the tumourigenic state is associated with a decrease in the ability to accumulate and repair sublethal damage. Previous studies have demonstrated that this transition to the tumourigenic state is also associated with loss of specific chromosomes (one copy each of chromosomes 11 and 14). It is suggested that this loss of chromosomes may account for the change in radiosensitivity.

KW - Human hybrid cells

KW - Non-tumourigenic

KW - Sub-lethal damage repair

KW - Tumourigenic

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Radiobiological studies of human hybrid cells (skin fibroblasts × hela) and their tumourigenic segregants

Abstract

Keywords

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