Abstract
The results reported earlier in this series indicated that the relative biological effectiveness (RBE) of ultrasoft X rays decreases with decreasing cell thickness, approaching unity for the thinnest cells used, plateau-phase human skin fibroblasts (HSF). The possible dependence of RBE on the configuration of the cell nucleus is investigated further in this paper using two CHO cell lines that attach well and have similar intrinsic radiosensitivities to 60Co γ rays. One of the lines forms monolayers similar to V79 cells, while the other remains more spherical during growth. We find an increasing RBE with decreasing X-ray energy for both of these cell lines, consistent with our results using V79 cells. Also consistent with our results obtained with 10T 1/2 and HSF cells, we find an increasing RBE with increasing cell thickness. The possible dependence of RBE on radiosensitivity and the use of the concept of mean dose for ultrasoft X rays is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 523-533 |
| Number of pages | 11 |
| Journal | Radiation Research |
| Volume | 119 |
| Issue number | 3 |
| State | Published - 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Biophysics
- Radiology Nuclear Medicine and imaging
- Radiation
Cite this
Radiobiology of ultrasoft X rays. IV. Flat and round-shaped hamster cells (CHO-10B, HS-23). / Carpenter, S.; Cornforth, Michael; Harvey, W. F.; Raju, M. R.; Schillaci, M. E.; Wilder, M. E.; Goodhead, D. T.
In: Radiation Research, Vol. 119, No. 3, 1989, p. 523-533.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radiobiology of ultrasoft X rays. IV. Flat and round-shaped hamster cells (CHO-10B, HS-23)
AU - Carpenter, S.
AU - Cornforth, Michael
AU - Harvey, W. F.
AU - Raju, M. R.
AU - Schillaci, M. E.
AU - Wilder, M. E.
AU - Goodhead, D. T.
PY - 1989
Y1 - 1989
N2 - The results reported earlier in this series indicated that the relative biological effectiveness (RBE) of ultrasoft X rays decreases with decreasing cell thickness, approaching unity for the thinnest cells used, plateau-phase human skin fibroblasts (HSF). The possible dependence of RBE on the configuration of the cell nucleus is investigated further in this paper using two CHO cell lines that attach well and have similar intrinsic radiosensitivities to 60Co γ rays. One of the lines forms monolayers similar to V79 cells, while the other remains more spherical during growth. We find an increasing RBE with decreasing X-ray energy for both of these cell lines, consistent with our results using V79 cells. Also consistent with our results obtained with 10T 1/2 and HSF cells, we find an increasing RBE with increasing cell thickness. The possible dependence of RBE on radiosensitivity and the use of the concept of mean dose for ultrasoft X rays is discussed.
AB - The results reported earlier in this series indicated that the relative biological effectiveness (RBE) of ultrasoft X rays decreases with decreasing cell thickness, approaching unity for the thinnest cells used, plateau-phase human skin fibroblasts (HSF). The possible dependence of RBE on the configuration of the cell nucleus is investigated further in this paper using two CHO cell lines that attach well and have similar intrinsic radiosensitivities to 60Co γ rays. One of the lines forms monolayers similar to V79 cells, while the other remains more spherical during growth. We find an increasing RBE with decreasing X-ray energy for both of these cell lines, consistent with our results using V79 cells. Also consistent with our results obtained with 10T 1/2 and HSF cells, we find an increasing RBE with increasing cell thickness. The possible dependence of RBE on radiosensitivity and the use of the concept of mean dose for ultrasoft X rays is discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024378386&partnerID=8YFLogxK
M3 - Article
VL - 119
SP - 523
EP - 533
JO - Radiation Research
JF - Radiation Research
SN - 0033-7587
IS - 3
ER -