Radiobiology of ultrasoft X rays. IV. Flat and round-shaped hamster cells (CHO-10B, HS-23)

S. Carpenter, Michael Cornforth, W. F. Harvey, M. R. Raju, M. E. Schillaci, M. E. Wilder, D. T. Goodhead

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The results reported earlier in this series indicated that the relative biological effectiveness (RBE) of ultrasoft X rays decreases with decreasing cell thickness, approaching unity for the thinnest cells used, plateau-phase human skin fibroblasts (HSF). The possible dependence of RBE on the configuration of the cell nucleus is investigated further in this paper using two CHO cell lines that attach well and have similar intrinsic radiosensitivities to 60Co γ rays. One of the lines forms monolayers similar to V79 cells, while the other remains more spherical during growth. We find an increasing RBE with decreasing X-ray energy for both of these cell lines, consistent with our results using V79 cells. Also consistent with our results obtained with 10T 1/2 and HSF cells, we find an increasing RBE with increasing cell thickness. The possible dependence of RBE on radiosensitivity and the use of the concept of mean dose for ultrasoft X rays is discussed.

Original languageEnglish (US)
Pages (from-to)523-533
Number of pages11
JournalRadiation Research
Volume119
Issue number3
StatePublished - 1989
Externally publishedYes

Fingerprint

Radiobiology
radiobiology
Relative Biological Effectiveness
hamsters
CHO Cells
Cricetinae
X-radiation
X-Rays
fibroblasts
radiation tolerance
cells
x rays
cultured cells
skin (animal)
Radiation Tolerance
cell lines
Fibroblasts
Cell Line
cell nucleus
Skin

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Carpenter, S., Cornforth, M., Harvey, W. F., Raju, M. R., Schillaci, M. E., Wilder, M. E., & Goodhead, D. T. (1989). Radiobiology of ultrasoft X rays. IV. Flat and round-shaped hamster cells (CHO-10B, HS-23). Radiation Research, 119(3), 523-533.

Radiobiology of ultrasoft X rays. IV. Flat and round-shaped hamster cells (CHO-10B, HS-23). / Carpenter, S.; Cornforth, Michael; Harvey, W. F.; Raju, M. R.; Schillaci, M. E.; Wilder, M. E.; Goodhead, D. T.

In: Radiation Research, Vol. 119, No. 3, 1989, p. 523-533.

Research output: Contribution to journalArticle

Carpenter, S, Cornforth, M, Harvey, WF, Raju, MR, Schillaci, ME, Wilder, ME & Goodhead, DT 1989, 'Radiobiology of ultrasoft X rays. IV. Flat and round-shaped hamster cells (CHO-10B, HS-23)', Radiation Research, vol. 119, no. 3, pp. 523-533.
Carpenter S, Cornforth M, Harvey WF, Raju MR, Schillaci ME, Wilder ME et al. Radiobiology of ultrasoft X rays. IV. Flat and round-shaped hamster cells (CHO-10B, HS-23). Radiation Research. 1989;119(3):523-533.
Carpenter, S. ; Cornforth, Michael ; Harvey, W. F. ; Raju, M. R. ; Schillaci, M. E. ; Wilder, M. E. ; Goodhead, D. T. / Radiobiology of ultrasoft X rays. IV. Flat and round-shaped hamster cells (CHO-10B, HS-23). In: Radiation Research. 1989 ; Vol. 119, No. 3. pp. 523-533.
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