Raised venous lactate and markers of intestinal translocation are associated with mortality among in-patients with HIV-associated TB in rural South Africa

Sathyavani Subbarao, Katalin A. Wilkinson, Clare L. Van Halsema, Suhasini Subba Rao, Tom Boyles, Netanya S. Utay, Robert J. Wilkinson, Graeme Meintjes

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: Case fatality among in-patients with HIV-associated tuberculosis (HIV-TB) in Africa is high. We investigated the factors associated with mortality in a rural South African hospital. Methods: This was a prospective observational study of HIV-TB in-patients, with death by 8 weeks the endpoint. Results: Of 99 patients (median CD4 count 72 cells/mm3), 32 (32%) died after median 8-day TB treatment. TB was diagnosed microbiologically in 75/99 and clinico-radiologically in 24, with no mortality difference between these groups [31% versus 38% (P = 0.53)]. Median venous lactate was 5.5 mmol/L (interquartile range 3.9-6.2) in those who died and 3.1 mmol/L (interquartile range 2.2-4.1) in survivors (P <0.001). In multivariable analysis, lactate ≥4 mmol/L [adjusted odds ratio (aOR) 9.8, 95% confidence interval (CI): 3.0 to 32.2], Glasgow Coma Score

Original languageEnglish (US)
Pages (from-to)406-413
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume70
Issue number4
StatePublished - Dec 1 2015

Fingerprint

South Africa
Lactic Acid
HIV
Mortality
Tuberculosis
CD4 Lymphocyte Count
Coma
Observational Studies
Survivors
Odds Ratio
Prospective Studies
Confidence Intervals
Therapeutics

Keywords

  • Human immunodeficiency virus
  • Lactate
  • Lipopolysaccaride
  • Mortality
  • Translocation
  • Tuberculosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Subbarao, S., Wilkinson, K. A., Van Halsema, C. L., Rao, S. S., Boyles, T., Utay, N. S., ... Meintjes, G. (2015). Raised venous lactate and markers of intestinal translocation are associated with mortality among in-patients with HIV-associated TB in rural South Africa. Journal of Acquired Immune Deficiency Syndromes, 70(4), 406-413.

Raised venous lactate and markers of intestinal translocation are associated with mortality among in-patients with HIV-associated TB in rural South Africa. / Subbarao, Sathyavani; Wilkinson, Katalin A.; Van Halsema, Clare L.; Rao, Suhasini Subba; Boyles, Tom; Utay, Netanya S.; Wilkinson, Robert J.; Meintjes, Graeme.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 70, No. 4, 01.12.2015, p. 406-413.

Research output: Contribution to journalArticle

Subbarao, S, Wilkinson, KA, Van Halsema, CL, Rao, SS, Boyles, T, Utay, NS, Wilkinson, RJ & Meintjes, G 2015, 'Raised venous lactate and markers of intestinal translocation are associated with mortality among in-patients with HIV-associated TB in rural South Africa', Journal of Acquired Immune Deficiency Syndromes, vol. 70, no. 4, pp. 406-413.
Subbarao, Sathyavani ; Wilkinson, Katalin A. ; Van Halsema, Clare L. ; Rao, Suhasini Subba ; Boyles, Tom ; Utay, Netanya S. ; Wilkinson, Robert J. ; Meintjes, Graeme. / Raised venous lactate and markers of intestinal translocation are associated with mortality among in-patients with HIV-associated TB in rural South Africa. In: Journal of Acquired Immune Deficiency Syndromes. 2015 ; Vol. 70, No. 4. pp. 406-413.
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