Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury

Possible link between traumatic brain injury and sporadic tauopathies

Bridget Hawkins, Shashirekha Krishnamurthy, Diana L. Castillo-Carranza, Urmi Sengupta, Donald Prough, George R. Jackson, Douglas Dewitt, Rakez Kayed

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) is a serious problem that affects millions of people in the United States alone. Multiple concussions or even a single moderate to severe TBI can also predispose individuals to develop a pathologically distinct form of tauopathy-related dementia at an early age. No effective treatments are currently available for TBI or TBI-related dementia; moreover, only recently has insight been gained regarding the mechanisms behind their connection. Here, we used antibodies to detect oligomeric and phosphorylated Tau proteins in a non-transgenic rodent model of parasagittal fluid percussion injury. Oligomeric and phosphorylated Tau proteins were detected 4 and 24 h and 2 weeks post-TBI in injured, but not sham control rats. These findings suggest that diagnostic tools and therapeutics that target only toxic forms of Tau may provide earlier detection and safe, more effective treatments for tauopathies associated with repetitive neurotrauma.

Original languageEnglish (US)
Pages (from-to)17042-17050
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number23
DOIs
StatePublished - Jun 7 2013

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Tauopathies
Oligomers
Rats
Brain
tau Proteins
Dementia
Rat control
Percussion
Poisons
Rodentia
Traumatic Brain Injury
Fluids
Antibodies
Wounds and Injuries

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury : Possible link between traumatic brain injury and sporadic tauopathies. / Hawkins, Bridget; Krishnamurthy, Shashirekha; Castillo-Carranza, Diana L.; Sengupta, Urmi; Prough, Donald; Jackson, George R.; Dewitt, Douglas; Kayed, Rakez.

In: Journal of Biological Chemistry, Vol. 288, No. 23, 07.06.2013, p. 17042-17050.

Research output: Contribution to journalArticle

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