TY - JOUR
T1 - Rapid antigen detection in the diagnosis of highly pathogenic avian influenza (H5N1) virus in Nigeria
AU - Meseko, Clement Adebajo
AU - Oladokun, Agnes Tinuke
AU - Ekong, Pius Stephen
AU - Fasina, Folorunso Oludayo
AU - Shittu, Ismaila Ademola
AU - Sulaiman, Lanre Kabir
AU - Egbuji, Anthony Nwachinemelo
AU - Solomon, Ponman
AU - Ularamu, Hussaini Gulak
AU - Joannis, Tony Manuel
PY - 2010/10
Y1 - 2010/10
N2 - Highly pathogenic avian influenza (AI) is an infectious disease of agroeconomic and public health importance. The outbreak that occurred in Nigeria (2006-2008) was devastating to the poultry industry and raised public health concerns. In the course of its control, rapid laboratory confirmation of suspected cases in poultry was essential for prompt mobilization of control logistics for depopulation and decontamination of affected premises. Commercial rapid test kit was evaluated in the diagnosis of highly pathogenic AI (HPAI) as a preliminary to virus isolation. Between 2006 and 2007, 382 cases were tested out of which 149 were positive by rapid antigen detection. Virus isolation yielded 171 positive cases. The relative diagnostic sensitivity of Anigen Rapid AIV Ag test was 84.3% (95% confidence interval [CI], 78.1-88.9%), whereas the relative diagnostic specificity was 97.7% (95% CI, 94.2-99.1%). Rapid antigen detection is a useful technique for prompt diagnosis of HPAI for early detection and containment.
AB - Highly pathogenic avian influenza (AI) is an infectious disease of agroeconomic and public health importance. The outbreak that occurred in Nigeria (2006-2008) was devastating to the poultry industry and raised public health concerns. In the course of its control, rapid laboratory confirmation of suspected cases in poultry was essential for prompt mobilization of control logistics for depopulation and decontamination of affected premises. Commercial rapid test kit was evaluated in the diagnosis of highly pathogenic AI (HPAI) as a preliminary to virus isolation. Between 2006 and 2007, 382 cases were tested out of which 149 were positive by rapid antigen detection. Virus isolation yielded 171 positive cases. The relative diagnostic sensitivity of Anigen Rapid AIV Ag test was 84.3% (95% confidence interval [CI], 78.1-88.9%), whereas the relative diagnostic specificity was 97.7% (95% CI, 94.2-99.1%). Rapid antigen detection is a useful technique for prompt diagnosis of HPAI for early detection and containment.
KW - Antigen
KW - Detection
KW - Diagnosis
KW - H5N1
KW - HPAI
KW - Nigeria
KW - Rapid
UR - http://www.scopus.com/inward/record.url?scp=77956587145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956587145&partnerID=8YFLogxK
U2 - 10.1016/j.diagmicrobio.2010.05.015
DO - 10.1016/j.diagmicrobio.2010.05.015
M3 - Article
C2 - 20846589
AN - SCOPUS:77956587145
SN - 0732-8893
VL - 68
SP - 163
EP - 165
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 2
ER -