Rapid diagnosis of rift valley fever: A comparison of methods for the direct detection of viral antigen in human sera

J. Meegan, B. Le Guenno, T. Ksiazek, A. Jouan, F. Knauert, J. P. Digoutte, C. J. Peters

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Human sera collected during the 1987 Rift Valley fever (RVF) epidemic in the Senegal River basin were analysed using three enzyme immunoassays to establish the best method for rapid diagnosis of RVF. A biotin-avidinenhanced antigen detection method utilizing monoclonal antibodies proved most sensitive. Eighty-two viremic human sera were tested, and this assay detected antigen in 29.3 % of the samples.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalResearch in Virology
Volume140
Issue numberC
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • EIA, Diagnosis, Senegal
  • RVF virus, mAb

ASJC Scopus subject areas

  • Immunology
  • Virology

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