TY - JOUR
T1 - Rapid high-temperature treatment of human milk
AU - Goldblum, Randall M.
AU - Dill, Charles W.
AU - Albrecht, Thomas B.
AU - Alford, Edna S.
AU - Garza, Cutberto
AU - Goldman, Armond S.
N1 - Funding Information:
From the Departments of Pediatrics, Microbiology, and Human Biological Chemistry and Genetics. The University of Texas Medical Branch; t!*e Department of Animal Science, Texas A & M University; and the Department of Pediatrics, Baylor College of Medicine. Supported by the National Institutes of Child ilealth and Human Development (DHEW 1 HD-2828); U.S. Department of ,4gricul-ture. Children's Nutrition Center in Baylor College of Medicine; and a grant from the W L. Moody Foundation. Reprint requests: Randall M. Goldblum, M.D.. Department of Pediatrics. Allergyflmmunology Division, Room C2-31 Child llealth Center. University of Texas Medical Branch Galveston, TX 77550.
PY - 1984/3
Y1 - 1984/3
N2 - Increasing interest in feeding human milk to low-birth-weight infants raises concern about microbial contamination of milk that is pooled or stored. We examined the effect of rapid high-temperature treatment on bacteria and viruses and on the nutritional and immunologic quality of pooled human milk. Growth of endogenous bacteria and infectivity of added cytomegalovirus were undetectable after heating at 72°C for 15 and 5 seconds, respectively. Folic acid and vitamins B1, B2, B6, and C were not affected, whereas bile salt-stimulated lipase was inactivated by these conditions. The concentration of lactoferrin and secretory IgA, and SIgA antibody activity were not changed by heating at 72°C. Lysozyme concentration and enzymatic activity were increased significantly by heat treatment, suggesting that this component may be largely sequestered in milk. Our findings suggest that rapid high-temperature treatment can reduce microbial contamination without destrying the unique nutritional and immunologic qualities of human milk.
AB - Increasing interest in feeding human milk to low-birth-weight infants raises concern about microbial contamination of milk that is pooled or stored. We examined the effect of rapid high-temperature treatment on bacteria and viruses and on the nutritional and immunologic quality of pooled human milk. Growth of endogenous bacteria and infectivity of added cytomegalovirus were undetectable after heating at 72°C for 15 and 5 seconds, respectively. Folic acid and vitamins B1, B2, B6, and C were not affected, whereas bile salt-stimulated lipase was inactivated by these conditions. The concentration of lactoferrin and secretory IgA, and SIgA antibody activity were not changed by heating at 72°C. Lysozyme concentration and enzymatic activity were increased significantly by heat treatment, suggesting that this component may be largely sequestered in milk. Our findings suggest that rapid high-temperature treatment can reduce microbial contamination without destrying the unique nutritional and immunologic qualities of human milk.
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U2 - 10.1016/S0022-3476(84)81099-9
DO - 10.1016/S0022-3476(84)81099-9
M3 - Article
C2 - 6323663
AN - SCOPUS:0021361444
SN - 0022-3476
VL - 104
SP - 380
EP - 385
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 3
ER -